نتایج جستجو برای: xenobiotic metabolism
تعداد نتایج: 227538 فیلتر نتایج به سال:
The metabolism of the nonprovitamin A carotenoid astaxanthin was investigated in primary cultures of rat hepatocytes. In a time course study based on HPLC and gas chromatography-mass spectrometry analyses, one main metabolite, (rac)-3-hydroxy-4-oxo-beta-ionone, was found. This metabolite was conjugated mainly into glucuronides, as demonstrated by glusulase treatment of the conjugates under sulf...
چکیده ندارد.
In vitro approaches to address key steps of chemical-induced skin sensitization have been developed, but there is uncertainty how keratinocytes, which play a crucial role not only regarding xenobiotic metabolism but also skin inflammation, impact on a chemical's potential and potency to activate dendritic cells. We investigated these aspects by coculturing THP-1 cells, as surrogate dendritic ce...
Studies of gas chromatography/mass spectrometry (GC-MS) techniques carried out in 1994 on human clinical samples had already suggested a “potential for diagnosis and studies of metabolism in situ” . Researchers found that, when this technique is applied to blood or urine, it gives an insight into the infected host microbial metabolism . A more recent study (2002) on urinary organic metabolites,...
In vitro bioassays are increasingly used for water quality monitoring. Surface water samples often need to be enriched to observe an effect and solid-phase extraction (SPE) is commonly applied for this purpose. The applied methods are typically optimised for the recovery of target chemicals and not for effect recovery for bioassays. A review of the few studies that have evaluated SPE recovery f...
The importance of cytochrome P450 isoforms to species differences in the metabolism of foreign compounds and activation of procarcinogens has been identified. The possible range of P450 isozymes in significant variations in toxicity exhibited by experimental rodent species may have a relevance to chemical risk assessment, especially as human P450s are likely to show changes in the way they meta...
1Department of Developmental and Cell Biology, 2Department of Medicine, and Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA. 3Department of Gene Regulation and Drug Discovery, City of Hope National Medical Center, Beckman Research Institute, Gonda Diabetes Research Center, Duarte, California, USA. 4Department of Pharmaceutics, Universi...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید