Sir, Xeroderma pigmentosum (XP) and Cockayne syndrome (CS) are rare genodermatoses characterized by hypersensitivity to ultraviolet light. XP is a hereditary autosomal recessive condition, manifested clinically by abnormal photosensitivity of the skin and eyes, pigment anomalies, increased risk of cutaneous neoplasms and, frequently, by progressive neural degeneration (1 ± 3). CS is a rare auto...

It is supposed that there exists a system O' (intrinsic system) in which the field equation for a spin i representation has the simple form yf* dyj'/dxf*' =0. This system is related to the physical system (in which all measurements are performed) by an affine connection which is induced by a certain group of local transformations. The investigation given here deals with the group of local four-...

Recombinant adenoviral vectors provide efficient means for gene transduction in mammalian cells in vitro and in vivo. We are currently using these vectors to transduce DNA repair genes into repair deficient cells, derived from xeroderma pigmentosum (XP) patients. XP is an autosomal syndrome characterized by a high frequency of skin tumors, especially in areas exposed to sunlight, and, occasiona...

Agile models promote fast development. XP and Scrum are the most widely used agile models. This paper investigates the phases of XP and Scrum models in order to identify their potentials and drawbacks. XP model has certain drawbacks, such as not suitable for maintenance projects and poor performance for medium and large-scale development projects. Scrum model has certain limitations, such as la...

Abstract The present study aimed to evaluate the root surface topography and cutting-edge retention after mechanical planing using five different types of curettes. Sixty premolars were divided among stainless steel curette (SS), titanium-coated (SC), titanium (Ti), EverEdge (EE), XP (XP) groups. Mean tooth roughness (Ra) mean depth (Rz) values determined. SEM EDX checked 40, 500, 1,000, 2500 s...

Sixty-one xeroderma pigmentosum (\P) patients living in the Federal Republic of Germany were investigated. Clinical symptoms were corre lated with DNA repair parameters measured in fibroblasts grown from skin biopsies. Classification according to the international complemen tation groups revealed that of the 61 patients 3 belonged to group A, 26 to group C, 16 to group D, 3 to group E, and 2 to...

Natural health products (NHPs) or complementary and alternative medicine (CAM) are commonly used to prevent disorders or support the usual treatments of many diseases. XP-828L, a whey protein extract, has demonstrated potential benefits for the treatment of mild to moderate psoriasis. The aim of this study was to analyze further clinical data that demonstrated the clinical benefits and safety o...

One class of xeroderma pigmentosum (XP) patients, known as XP variants, inherit the characteristic predisposition to sunlight-induced skin cancer, but unlike the majority of XP patients, their cells do not exhibit a deficiency in rate of excision repair of ultraviolet (UV) radiation-induced DNA damage. XP variant cells are only slightly more sensitive than normal to killing by 254 nm UV radiati...