Human hepatitis B virus is a risk factor for the development of hepatocellular carcinoma. The hepatitis B virus x protein (HBx) has been shown to inactivate the p53 tumor suppressor protein and impair DNA repair, cell cycle, and apoptosis mechanisms. Herein we report that HBx represses two components of the transcription-repair factor TFIIH, XPB (p89), and XPD (p80), both in p53-proficient and ...

In order to unravel the mechanism that regulates transcription of protein-coding genes, we investigated the function of the p44 subunit of TFIIH, a basal transcription factor that is also involved in DNA repair. We have shown previously that mutations in the C terminus of the XPD helicase, another subunit of TFIIH, prevent its regulation by p44 (Coin, F., Bergmann, E., Tremeau-Bravard, A., and ...

Reflux of gastric contents can lead to development of reflux esophagitis and Barrett’s esophagus. Barrett’s esophagus is a risk factor for esophageal adenocarcinoma. Damage to DNA may lead to carcinogenesis but is repaired through activation of pathways involving polymorphic enzymes, including human 8-oxoguanine glycosylase 1 (hOGG1), X-ray repair cross-complementing 1 (XRCC1), and xeroderma pi...

Susceptibility to cancer ensues in individuals carrying malfunctioning DNA repair mechanisms. The impact of Single Nucleotide Polymorphisms (SNPs) in key DNA repair mechanisms on risk for prostate cancer was investigated in this case-control study. Samples consisted of 110 patients with confirmed prostate cancer and 200 unaffected men, from Rio de Janeiro, Brazil. XPD/Lys751Gln (rs13181), APEX1...

In this letter, we present a correlated channel model for a dual-polarization antenna to omnidirectional antennas in indoor small-cell multiple-input multiple-output (MIMO) systems. In an indoor environment, we confirm that the cross-polarization discrimination (XPD) in the direction of angle-of-departure can be represented as the spatial correlation of the MIMO channel. We also evaluate a dual...

This paper presents a simple model for polarized multiple-input multiple-output (MIMO) channels. At first, the model is desired for line-of-sight (LOS) scenario, and then generalized for non-LOS (NLOS) case. The analysis of the crosspolarization discrimination (XPD) for a 2×2 MIMO systems shows that the XPD depends on both the antenna patterns and the polarization mismatch between the transmit ...

This article presents a new design of differentially fed substrate integrated planar antenna array with dual-polarization. Compared the traditional dual-polarized arrays, proposed has advantages simple configuration, high cross-polarization discrimination (XPD), and gain. The 2×2-element subarray via-loaded crossover structure is used, which reduces complexity antenna. operation bandwidth impro...

Abstract In total 58 Xanthomona s strains isolated from Araceae worldwide, together with 13 other phylogenetically-related Xanthomonas strains, were characterized using multilocus sequence analysis based on concatenated sequences of seven single copy orthologous genes, extracted whole genome sequences. The revealed a monophyletic clade 48 44 Anthurium , identified as X. phaseoli pv. dieffenbach...