Multidrug resistance (MDR) to chemotherapeutic agents is a major obstacle to successful treatment in breast cancer patients. The aims of this study were to investigate whether miR-137 was involved in the regulation of MDR, and to explore the mechanism of miR-137 on the sensitivity of MCF-7/ADM cells. miR-137 was downregulated in MCF-7/ADM cells, and its expression was found to inversely correla...

Thin films of amorphous aluminum oxide (a-Al2O3) codoped with Er 31 and Yb ions have been in-depth nanostructured by distributing the rate earth ~RE! ions in layers separated in the 0–3 nm range. The Yb to Er concentration ratio is varied from 0 to 3.6. The photoluminescence ~PL! response at 1.53 mm exhibits an increase of up to two orders of magnitude with respect to that of films doped only w...

Our experiments demonstrate that alloying the cubic-phase $\mathrm{Yb}\mathrm{N}$ into wurtzite-phase $\mathrm{Al}\mathrm{N}$ results in clear mechanical softening and enhanced electromechanical coupling of $\mathrm{Al}\mathrm{N}$. First-principle calculations reproduce experimental well, predict a maximum 270% increase coefficient caused by (1) an piezoelectric response induced local strain $\...

The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 e...

This paper presents a new correlative bioimaging technique using Y2O3:Tm, Yb and Y2O3:Er, Yb nanophosphors (NPs) as imaging probes that emit luminescence excited by both near-infrared (NIR) light and an electron beam. Under 980 nm NIR light irradiation, the Y2O3:Tm, Yb and Y2O3:Er, Yb NPs emitted NIR luminescence (NIRL) around 810 nm and 1530 nm, respectively, and cathodoluminescence at 455 nm ...

High resolution single crystal synchrotron X-ray diffraction data measured at 15(2) K were used to solve the structure of the complex intermetallic Zintl phase, Yb(11)AlSb(9) (space group Iba2), made up of Yb cations and polyanions along with isolated Sb anions. The 15(2) K cell parameters are a = 11.7383(4) Å, b = 12.3600(4) Å, c = 16.6796(6) Å. The temperature dependence of the structure was ...

A novel method of fabricating water-soluble bio-probes with ultra-small size such as NaYF4:Yb,Er (18 nm), NaGdF4:Yb,Er (8 nm), CaF2:Yb,Er (10 nm), PbS (7 nm), and ZnS (12 nm) has been developed to provide for the solubility switch of nanoparticles from oil-soluble to water-soluble in terms of hydrion rivalry aided by ultrasonic. Using NaYF4:Yb,Er (18 nm) as an example, we evaluate the propertie...

In this work we report the study of energy transfer between Nd and Yb 3+ ions in glasses with the 0.8CaSiO3-0.2Ca3(PO4)2 eutectic composition at room temperature by using steady-state and time-resolved laser spectroscopy. The Nd →Yb transfer efficiency obtained from the Nd 3+ lifetimes in the single doped and codoped samples reaches 73% for the highest Nd 3+ concentration. The donor decay curve...

The cold.-fluid extraordinary-mode eigenvalue equation is solved numerically to determine the influence of equilibrium profile shape on the detailed stability properties of relativistic nonneutral electron flow in a planar diode with cathode located at x=O and anode at x=d. Stability properties are investigated for the class of equilibrium energy profiles Yb(x) specified by [1-a (b2_ 2 1/2 Yb(x...

introduction: bleomycins are dna-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as yb-175. in this work the development of yb-175 bleomycin (175yb-blm) has been reported. methods: yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural yb2o3 samples at various neutron fluxes and irradiation time...