SA@ETAK. Fatalna plu}na embolija u mnogim razvijenim zemljama ostaje najva`niji uzrok mortaliteta u trudno}i, a za povi{enu incidenciju tromboembolijskih incidenata u trudno}i znamo ve} stolje}ima. Fiziolo{ka zbivanja u trudno}i dovode do stanja hiperkoagulabilnosti, {to povisuje rizik za venski tromboembolizam (VTE). @ene s priro|enim ili ste~enim trombofilijama imaju za vrijeme trudno}e poseb...

PURPOSE The aim of this study was to assess the antiangiogenic treatment effects of zoledronic acid (ZA) and sunitinib malate (SM) noninvasively in experimental breast cancer bone metastases by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and vessel size imaging. EXPERIMENTAL DESIGN Nude rats bearing bone metastases after inoculation of MDA-MB-231 breast cancer cells were tr...

INTRODUCTION: No effective non-operative treatments are available for Perthes disease. We have previously reported significant improvement in outcome in traumatic osteonecrosis in growing rats by intervention with zoledronic acid (ZA), a potent third generation bisphosphonate. In this study we examine the effect of ZA on a model of spontaneous osteonecrosis in growing rats. We hypothesized that...

We studied an acute and chronic oral toxicity of the extract from Ziziphus attopensis (ZA) in male and female SD rats according to the OECD guidelines. After a single oral administration of ZA 5 g/kg body weight, measurement of the body and organs, necropsy, and health monitoring were performed. The body and organ weights and behavior were not changed relative to the control rats indicating tha...

The natural compound zosteric acid, or p-(sulfoxy)cinnamic acid (ZA), is proposed as an alternative biocide-free agent suitable for preventive or integrative anti-biofilm approaches. Despite its potential, the lack of information concerning the structural and molecular mechanism of action involved in its anti-biofilm activity has limited efforts to generate more potent anti-biofilm strategies. ...

The apex of hair cells of the chicken auditory organ contains three different kinds of assemblies of actin filaments in close spatial proximity. These are (a) paracrystals of actin filaments with identical polarity in stereocilia, (b) a dense gellike meshwork of actin filaments forming the cuticular plate, and (c) a bundle of parallel actin filaments with mixed polarities that constitute the ci...

The apical transmembrane protein Crumbs is necessary for both cell polarization and the assembly of the zonula adherens (ZA) in Drosophila epithelia. The apical spectrin-based membrane skeleton (SBMS) is a protein network that is essential for epithelial morphogenesis and ZA integrity, and exhibits close colocalization with Crumbs and the ZA in fly epithelia. These observations suggest that Cru...

In orthopedic surgery, large amount of diseased or injured bone routinely needs to be replaced. Autografts are mainly used but their availability is limited. Commercially available bone substitutes allow bone ingrowth but lack the capacity to induce bone formation. Thus, off-the-shelf osteoinductive bone substitutes that can replace bone grafts are required. We tested the carrier properties of ...

Non-small cell lung cancer (NSCLC) patients with epithelial growth factor receptor (EGFR) mutations and bone metastases are often concurrently administered tyrosine kinase inhibitors (TKIs) and bisphosphonates. Yet, the effects and mechanisms of these agents are unclear. In the present study, we aimed to ascertain whether zoledronic acid (ZA) increases the antitumor effects of gefitinib treatme...

We propose a pipeline for learning event templates from a large corpus of textual news articles. An event template is a machine-usable semantic data structure, in our case a graph, describing a certain event type. Such a template encodes the most characteristic information for a certain type of event; for instance, an earthquake template would encode "x people dead” and/or “town y shook at time...