Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2'-O-Methyl RNA nucleotides (2'OMe) with phosphorothioate (PS) internucleotide linkages positioned at both ends to block exonuclease attack. Second generation AMOs improved potency through...

Gene duplications within the conserved Hox cluster are rare in animal evolution, but in Lepidoptera an array of divergent Hox-related genes (Shx genes) has been reported between pb and zen. Here, we use genome sequencing of five lepidopteran species (Polygonia c-album, Pararge aegeria, Callimorpha dominula, Cameraria ohridella, Hepialus sylvina) plus a caddisfly outgroup (Glyphotaelius pellucid...

We present our “Zero Energy Network” (ZEN) protocol stack for energy harvesting wireless sensor networks applications. The novelty in our work is 4 fold: (1) Energy harvesting aware fully featured MAC layer. Carrier sensing, Backoff algorithms, ARQ, RTS/CTS mechanisms, Adaptive Duty Cycling are either auto configurable or available as tunable parameters to match the available energy (b) Energy ...

This study demonstrates that low doses (somewhat above the No Observed Adverse Effect Level, NOAEL) of the mycoestrogen zearalenone (ZEN) and its metabolites display multispecificity towards various biological targets in gilts. The observed responses in gilts were surprising. The presence of ZEN and zearalenols (ZELs) did not evoke a response in the porcine gastrointestinal tract, which was att...

Weblogs are one of the most discussed trends in business and education alike. From all these comments and publications it is clear that weblogs will have a bright future as a personal web publishing tool, but will they also invade the education and business areas? And more important: will their widespread use mean just another tool or a radical change? – The line of argument in this paper is tw...

Increased levels of stress are more frequent in the hearing-impaired population than in normal-hearing people. Because of the high frequency of stress in the hearing-impaired population and the ability of music to reduce stress, Widex has included a feature in the high end mind440 hearing aid which allows users to listen to a choice of diff erent music styles. Generally researchers agree that m...

Artikulu honen xedea Arabako euskalgintzaren bilakaera frankismoan azaltzea da. Lehenik eta behin, ulertu behar dugu euskalgintza kontzeptu zabala dela, artikulu honetan helduen euskalduntzean, ikastoletan kulturgintzan zentratuko gara. Testuingurua dramatikoa zen Araban, mendeetako gainbeheraz gainera, frankismoaren errepresioaren erruz hizkuntza hilzorian zegoen. Egoera kezkagarri horretan, h...

BACKGROUND In the long-germ insect Drosophila, a single extraembryonic membrane, the amnioserosa, covers the embryo at the dorsal side. In ancestral short-germ insects, an inner membrane, the amnion, covers the embryo ventrally, and an outer membrane, the serosa, completely surrounds the embryo. An early differentiation step partitions the uniform blastoderm into the anterior-dorsal serosa and ...