نتایج جستجو برای: α gene
تعداد نتایج: 1281484 فیلتر نتایج به سال:
Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. Anti-tumour necrosis factor (anti-TNF)-α agents have been approved for therapeutic use across a range of inflammatory disorders including psoriasis, but the anti-inflammatory mecha...
α-1,3-Glucan is present as the outermost layer of the cell wall in the pathogenic yeastlike (Y) form of Paracoccidioides brasiliensis. Based on experimental evidence, this polysaccharide has been proposed as a fungal virulence factor. To degrade α-1,3-glucan and allow remodeling of the cell wall, α-1,3-glucanase is required. Therefore, the study of this enzyme, its encoding gene, and regulatory...
Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gallbladder cancer-derived cell lines. Based on the data, TNF-α mRNA and TNF-α pr...
سرطان بیماری، مهلکی است که بعد از بیماری های قلبی و عروقی دومین عامل مرگ و میر در جهان می باشد. سرطان پستان یکی از شایع ترین سرطان های شناخته شده و علت اصلی ناشی ازمرگ و میر سرطان در زنان می باشد. عوامل ژنتیکی و محیطی بسیاری در ابتلا به این بیماری اثر دارد. یکی از مهم ترین عوامل خطر ساز محیطی، سیگار کشیدن می باشد که نیکوتین موجود در سیگار، با اتصال به گیرنده استیل کولین نیکوتین باعث تحریک تقسیم...
Paneth cells at the base of small intestinal crypts secrete microbicidal α-defensins, termed cryptdins (Crps) in mice, as mediators of innate immunity. Proteomic studies show that five abundant Paneth cell α-defensins in C57BL/6 mice are strain specific in that they have not been identified in other inbred strains of mice. Two C57BL/6-specific peptides are coded for by the Defcr20 and -21 genes...
Renal fibrosis poses critical health problem. We aimed to investigate role of let-7i-5p in renal fibrosis. In silico reproduction Mouse Kidney FibrOmics browser was used identify potential target let-7i-5p. vivo validation conducted C57BL/6 mice with unilateral ureteral obstruction (UUO) and folic acid (FA) induction. vitro performed transforming growth factor (TGF)-β1-treated HK-2 cells. Mimic...
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