Critical patients with pandemic COVID-19 have dysregulation in immune response, like cytokine storm, lymphopenia that led to increase mortality, vaccine is the only hope for controlling on this pandemic. However, study design evaluate effectiveness of Pfizer serum level IL-12/IFN-γ pathway susceptibility COVID-19. The current included 160 participants whom separated into two groups further anal...

OBJECTIVE Toll-like receptor 4 (TLR4) is one of the key players in the development of many autoimmune diseases. To determine the possible role of TLR4 in polymyositis (PM) development, we collected muscle samples from PM patients and mice subjected to an experimental autoimmune myositis (EAM) model. METHODS We measured TLR4-MyD88 pathway-related factors, interferon-γ (IFN-γ), and interleukin-...

OBJECTIVES To study the role of IFN-γ in the pathogenesis of systemic JIA (sJIA) and haemophagocytic lymphohistiocytosis (HLH) by searching for an IFN-γ profile, and to assess its relationship with other cytokines. METHODS Patients with inactive (n = 10) and active sJIA (n = 10), HLH [n = 5; of which 3 had sJIA-associated macrophage activation syndrome (MAS)] and healthy controls (n = 16) wer...

The aim of this study was to investigate the expression of peroxisome proliferator-activated receptor γ (PPAR-γ), tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the conjunctiva and the association between inflammatory cytokines and PPAR-γ in dry eye mice. Dry eye was induced in 6-week-old female C57 mice. mRNA expression of PPAR-γ, TNF-α and IL-1β were measured. PPAR-γ protein express...

BACKGROUND Natural killer (NK) cells have both cytolytic and immunoregulatory functions. We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK cell subset(s) that secrete these cytokines is not known. METHODOLOGY/PRINCIPAL FINDINGS To isolate the cells secreting IL-17 and IFN-γ, we took advantage of the findings that...

Systemic sclerosis (SSc) is a connective tissue disease characterized by autoimmunity, vasculopathy, and fibrosis. Several studies demonstrated the involvement of various cytokines including IL-1 in SSc. IL-36 cytokines, subgroup family, comprise IL-36α, β, γ, IL-36Ra, IL-38. γ are known to promote inflammatory response, which mainly produced epithelial cells. Whereas, IL-36Ra as well IL-38 may...

A number of studies have suggested that interleukin 6 (IL-6) and interferon-gamma (IFN-γ) have pathophysiologic roles in cardiovascular diseases. In view of recent evidence that serum IL-6 and IFN-γ may serve as inflammatory mediators in patients with enhanced inflammation, we hypothesize both IL-6 and IFN-γ have diagnostic and prognostic value in patients with acute coronary syndrome (ACS) and...

The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-γ is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced...

Natural variability in the abundance of signaling regulators can lead to divergence in cell fate, even within genetically identical cells that share a common differentiation state. We introduce cell-to-cell variability analysis (CCVA), an experimental and computational methodology that quantifies the correlation between variability in signaling regulator abundance and variation in the sensitivi...

Objective(s): The effects of PPAR-γ agonist alone and in combination with carvacrol and Zataria multiflora on inhaled paraquat (PQ) induced-systemic inflammation and oxidative stress were examined. Materials and Methods: Control group exposed to normal saline aerosol, one group exposed to 54 mg/m3 PQ aerosol and four groups exposed to PQ...