نتایج جستجو برای: ε4 allele
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Alzheimer’s disease (AD) is the most common cause of progressive neurological disorder leading to dementia. It is neuropathologically characterized by extracellular and perivascular deposits of amyloid beta peptide and by the generation of intracellular neurofibrillary tangles. AD is subdivided into early and late onset forms and it has a genetic aetiology, which is most evident in the case of ...
BACKGROUND Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease. METHODS We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's disease--one involving 1121 carriers of the apolipoprotein E (APOE) ε4 allele and the other involving 1331 nonc...
BACKGROUND Heritability of Alzheimer's disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numerous other common variants contributing only modest risk for disease. Variability in clinical presentation of AD, which is typically amnestic (AmnAD) but can less commonly invo...
Background Allelic variation to the APOE gene confers greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance apolipoprotein E (apoE), is characteristic AD CSF, and predicts cognitive decline. The mechanisms underlying genotype apoE level risks are uncertain. Recent fluid imaging biomarker studies have revealed an unexpected link between brain iron, w...
We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-...
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