Fibroblast-like synoviocytes (FLSs) produce lots of inflammatory molecules that trigger immune responses and intensification the inflammation thereby play important roles in Rheumatoid Arthritis )RA( pathogenesis. Due to toll-like receptor 4 (TLR4) cytokine production inflammation, we aimed evaluate effects TAK-242 (Resatorvid) on interleukin (IL)1-β, IL-6, TNF-α, TLR4 expression two proteins n...

Background: Sepsis is most likely to cause lung damage in patients, and the detection rate mortality are high. Here, we investigated expression of miR-20a sepsis-induced acute injury (ALI) rats its effect on inflammatory response, reveal possible molecular mechanism. Method: The model caused by sepsis was established cecal ligation puncture. tissue determined RT-qPCR. Acute were injected with 5...

Abstract Lipid nanoparticles (LNP) are essential components of messenger RNA (mRNA) vaccines that have been a cornerstone the COVID-19 public health response. These LNPs used for cell entry and protection mRNA. Others shown LNP BNT162b2 vaccine is able to augment immune response against target. However, it unknown how this stimulates innate cells such as monocytes participate in engagement adap...

Background: Sepsis is a life-threatening disease, and animal models of sepsis are minimal. This study aims to find the optimal dose make mouse model by examining presence target organ damage. Methods: This used 30 mice divided into four groups. The control group injected 0.5 cc NaCl 0.9% intraperitoneally (i.p.). Group A was with l...

The NF-κB transcription factor is a critical regulator of the immune system, and is responsive to a large number of stimuli. Different stimuli engage signaling pathways to activate NF-κB, and effect distinct cellular responses. Mathematical modeling of the NF-κB network has been useful in studying the dynamic and cross-talk regulation of NF-κB. In this review, we discuss the regulation of NF-κB...

BACKGROUND NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression of proapoptotic genes. Various chemotherapy agents induce NF-κB translocation and target gene activation. We conducted the present study to assess the predictive value of NF-κB regarding pathologic responses after receiving neoadjuvant chemotherapy. MATERIALS AND METHODS We enrolled 131 patients wi...

BACKGROUND Transcription factor nuclear factor-κB (NF-κB) plays a key role in the regulation of immune responses to inflammation. However, convenient assay systems to quantitate the NF-κB activity level in a timely manner are not available in the setting of clinical laboratories. Therefore, we developed a novel and high-throughput quantitative assay based on fluorescence correlation spectroscop...

BackgroundThe retinal vascular endothelial cells can be damaged by oxidative stress even in the early stage of diabetic retinopathy (DR). This study aimed to investigate protective effect curcumin on rat (RRVECs) high glucose circumstance.ObjectiveThe cultured RRVECs were identified and characterized both vWF CD31 immunofluorescence expression. The activation ROS/NF-κB signal pathway was examin...

Nuclear factor-κB (NF-κB) is a transcription factor regulating a wide array of genes mediating numerous cellular processes such as proliferation, differentiation, motility and survival, to name a few. Aberrant activation of NF-κB is a frequent event in numerous cancers, including glioblastoma, the most common and lethal form of brain tumours of glial cell origin (collectively termed gliomas). G...

NF-κB is a ubiquitously expressed transcription factor that regulates a large number of genes in response to diverse physiological and pathological stimuli. The regulation of the transcriptional activity of NF-κB is often dependent on its interaction with IκBα. Proteins that bind to IκBα are critical regulators of NF-κB activity. DDRGK1 is a member of the DDRGK domain-containing protein family ...