The goals of this study were to develop a simplified finite element knee model, cosimulate this model with the motion of knee flexion/extension to demonstrate the concept of cosimulation, and choose an integrator to maximize the efficiency of the cosimulation process. A simplified model of the knee was used to simulate flexion/extension in FEBio. The femur was modeled as a fixed, rigid body, th...

Hereditary hemorrhagic telangiectasia (HHT) is an inherited syndrome characterized by mucocutaneous telangiectases that commonly involve the tongue, lips, fingers, and conjunctiva. While root resorption has been reported in association with central hemangiomas of bone, the association of HHT with external cervical root resorption has not been described to date. We report a case of a 57-year-old...

Pulmonary arteriovenous malformations (PAVMs) occur in up to 27% of patients with hereditary haemorrhagic telangiectasia (HHT) and are associated with a rate of paradoxical cerebral embolism at presentation of up to 36%. At least two different loci have been shown for HHT. Mutations in endoglin have been found in some families and the locus designated ORW1. In other families this locus has been...

As phospho-eIF4E (p-eIF4E), unlike total eIF4E (t-eIF4E) essential for normal cells, is specifically required by cancer cells, it is an attractive, yet unrealized, target for anti-tumor intervention. Here we identify a small molecule, homoharringtonine (HHT), that antagonizes p-eIF4E function and eradicates acute myeloid leukemia (AML) expressing high level of p-eIF4E in vitro and in vivo. HHT ...

Temperature, solar radiation and water are major important variables in ecosystem models which are measurable via wireless sensor networks (WSN). Effective data analysis is necessary to extract significant spatial and temporal information. In this work, information regarding the long term variation of seasonal field environment conditions is explored using Hilbert-Huang transform (HHT) based an...

Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant condition. It is rarely seen in pregnancy and even more rarely has uterine manifestations. Case: A 29-year-old primigravid woman with HHT was noted to have vascular manifestations of her disease in the lower uterus, distal rectum, pelvis, and bladder before pregnancy. Prior to delivery, a case conference was he...

Hilbert-Huang Transform (HHT) is a novel data analysis technique for nonlinear and non-stationary data. We present a time-frequency analysis of both simulated light curves and an X-ray burst from the X-ray burster 4U 1702-429 with both the HHT and the Windowed Fast Fourier Transform (WFFT) methods. Our results show that the HHT method has failed in all cases for light curves with Poissonian flu...

Patients with hereditary hemorrhagic telangiectasia (HHT) and pulmonary arteriovenous malformation (PAVM) face higher risk of embolic complications. It is not clear whether poor outcomes are related to PAVM severity or pulmonary symptoms. Furthermore, there is currently no available data on HHT patients in Argentina. We conducted a cross sectional study in a teaching hospital in Buenos Aires, A...

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant systemic disorder of angiogenesis characterized by vascular malformations in mucocutaneous tissues, visceral organs, and the central nervous system (1). HHT-related neurological deficits and stroke are observed in 15% of patients and generally occur as a result of a right-to-left shunt induced by pulmonary arteriovenous malfor...

manifestations have been previously reported, though not well-documented, and usually with coronary artery aneurysm. Our HHT patient had a well-documented myocardial infarction with normal coronary arteries, as shown by our biology data, ECG, TTE, coronarography and RMI results. The ischaemic myocardial lesions might result from our patient’s inherited thrombophilia: factor V Leiden and MTHFR. ...