BACKGROUND AND AIMS Patients infected with genotype 2b hepatitis C virus (HCV) generally can achieve favorable responses to pegylated-interferon plus ribavirin therapy (PEG-IFN/RBV). However, a proportion of patients show poorer responses and the correlation between viral sequence variation and treatment outcome remains unclear. METHODS The pretreatment complete open reading frame (ORF) seque...

background: a dinucleotide variant rs368234815 in interferon lambda 4 (ifnl4) gene was recently found to be associated with the hepatitis c virus (hcv) treatment response. this study aimed to assess the impact of ifnl4 rs368234815 polymorphism on treatment response to pegylated?ifn alpha (peg?ifn??) and ribavirin (rbv) in hemophilic patients with chronic hepatitis c (chc). materials and methods...

conclusions the rvr is the strongest factor of svr and infection with hcv genotype 2 is significantly associated with rvr. neither biochemical and/or metabolic factors seem to exert influence on rvr. objectives the main aim of this study was to assess the strength of rvr, as a predictive factor of antiviral treatment response. patients and methods using univariate and multivariate analysis, we ...

BACKGROUND Multiple variables influencing the sustained virologic response (SVR) in chronic hepatitis C have been evaluated. One of them is genetic polymorphism near the IL28B gene. OBJECTIVES The aim of this study was to evaluate the influence of IL28B genotypes on SVR rates in a group of patients with chronic hepatitis C from the western part of Romania. PATIENTS AND METHODS A retrospecti...

BACKGROUND/AIMS Few studies have investigated prognostic factors for the development of liver-related events (LREs) in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). METHODS We analyzed 190 patients with CHC who achieved SVR after treatment with pegylated interferon (peg-IFN) plus ribavirin. LREs were defined as any complications related to cirrhosis...

The study aim was to assess sympathetic vasomotor response (SVR) by using pulsed wave Doppler (PWD) ultrasound in patients with multiple system atrophy (MSA) and correlate with the tilt table study. We recruited 18 male patients and 10 healthy men as controls. The SVR of the radial artery was evaluated by PWD, using inspiratory cough as a provocative maneuver. The response to head-up tilt was s...

An alternative model using support vector regression (SVR) based on dynamically optimized search technique with k-fold cross-validation, was proposed to predict the thermal–hydraulic performance of compact heat exchangers (CHEs). 48 experimental data points from the author’s own study were used in the present work. The performance of SVR with different regularization parameter c and kernel para...

In order to reduce the effect of numerical weather prediction (NWP) error on short term load forecasting (STLF) and improve the forecasting accuracy, a new hybrid model based on support vector regression (SVR) optimized by an artificial bee colony (ABC) algorithm (ABC-SVR) and seasonal autoregressive integrated moving average (SARIMA) model is proposed. According to the different day types and ...

In this paper, the support vector regression (SVR) methodology was adopted to estimate the horizontal global solar radiation (HGSR) based upon sunshine hours (n) and maximum possible sunshine hours (N) as input parameters. The capability of two SVRs of radial basis function (rbf) and polynomial basis function (poly) was investigated and compared with the conventional sunshine duration-based emp...

Budgeting planning plays an important role in coordinating activities in organizations. An accurate sales volume forecasting is the key to the entire budgeting process. All of the other parts of the master budget are dependent on the sales volume forecasting in some way. If the sales volume forecasting is sloppily done, then the rest of the budgeting process is largely a waste of time. Therefor...