Endogenous estrogens are important determinants of breast cancer risk in postmenopausal women. In this study we evaluated the effects of dietary soy isoflavonoids on endogenous estrogen metabolism in a postmenopausal primate model. Ovariectomized female cynomolgus monkeys were randomized to receive one of three diets for 36 months: (i) isoflavonoid-depleted soy protein isolate (SPI-) (n = 29); ...

Existing software engineering and management literature argue for many different ways of looking at success factors that influence Software Process Improvement (SPI). This study investigates success factors identified in a number of research projects and proposes a model for managing these factors in a structured way during different phases of an SPI program. It also aspires to describe a model...

Background Serine protease inhibitors (SPI) comprising 60-90 amino acid residues, are frequent in plants, and belong to the protein family PR-6. It has recently been shown that a SPI-variant of wheat acts as an important allergen in baker’s asthma but not in persons suffering from wheatinduced food allergy. The aim of this study was to elucidate the role of a recombinant SPI-variant of Hevea br...

Eighty patients undergoing elective ear-nose-throat surgery were enrolled in the present study to investigate the relationship between surgical pleth index (SPI) and stress hormones (ACTH, cortisol, epinephrine, norepinephrine) during general anaesthesia which was induced and maintained with propofol and remifentanil using a target-controlled infusion. The study concluded that the SPI had moder...

The spectrometer SPI is one of the main detectors of ESA’s INTEGRAL mission. The instrument offers two interesting and valuable capabilities for the detection of the prompt emission of Gamma-ray bursts. Within a field of view of 16 degrees, SPI is able to localize Gamma-ray bursts with an accuracy of 10 arcmin. The large anticoincidence shield, ACS, consisting of 512 kg of BGO crystals, detects...

Salmonella enterica serotype Gallinarum is the causative agent of fowl typhoid, a disease characterized by high morbidity and mortality that causes major economic losses in poultry production. We have reported that S. Gallinarum harbors a type VI secretion system (T6SS) encoded in Salmonella pathogenicity island 19 (SPI-19) that is required for efficient colonization of chicks. In the present s...

BACKGROUND Surgeries are inevitable for treating primary congenital glaucoma (PCG) and risk factors of surgical failure play a key role in surgical decision making. The aim of this study was to investigate the influence of delay of surgery and preoperative speed of progression (SP) on the surgical outcomes in these patients. METHODS Medical records of 83 eyes of 51 PCG patients with trabeculo...

The antioxidant activity of pectic enzyme treated pectin (PET-pectin) prepared from citrus pectin by enzymatic hydrolysis and its potential use as a stabilizer and an antioxidant for soy protein isolate (SPI)-stabilized oil in water (O/W) emulsion were investigated. Trolox equivalent antioxidant capacity (TEAC) was found to be positively associated with molecular weight (M(w)) of PET-pectin and...

We have recently reported that intake of soya protein isolate (SPI) inhibited the DNA-binding activities of hepatic thyroid hormone receptor (TR). The genes for acetyl-CoA carboxylase (ACC), a rate-limiting enzyme in fatty acid synthesis, contain the thyroid hormone response element in their promoters and are regulated by TR. The present study has examined the effect of long-term feeding of SPI...

OBJECTIVE To investigate the influence of blood derivatives on the acquisition of severe postoperative infection (SPI) in patients undergoing heart surgery. SETTING The postoperative ICUs of a tertiary-level university hospital. DESIGN A cohort study. METHODS During a 4-year period, 738 patients, classified as patients with SPIs and patients without SPIs (non-SPI patients), were included ...