Acute myeloid leukaemia (AML) is characterized by subpopulations of leukaemia stem cells (LSCs) that are defined by their ability to engraft in immunodeficient mice. Here we show an LSC DNA methylation signature, derived from xenografts and integration with gene expression that is comprised of 71 genes and identifies a key role for the HOXA cluster. Most of the genes are epigenetically regulate...

It is well-known that many environment-based abstract machines can be seen as strategies in lambda calculi with explicit substitutions (ES). Recently, graphical syntaxes and linear logic led to the linear substitution calculus (LSC), a new approach to ES that is halfway between big-step calculi and traditional calculi with ES. This paper studies the relationship between the LSC and environment-...

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by p210-BCR-ABL-mediated transformation of hematopoietic stem cells (HSCs). Inhibition of the ABL kinase alone is not sufficient to eradicate leukemic stem cells (LSCs). We have previously shown that the deficiency of Rac2 GTPase signaling, but not Rac1, in p210-BCR-ABL-transduced hematopoietic cells prolo...

This work proposes a dynamic and fair spectrum management strategy to be adopted by a service provider (SP). Here, we consider a scenario where multiple access networks (ANs) of different (not necessarily competing) technologies are owned by a single SP. We envisage that an SP employs an entity, called local spectrum controller (LSC), which manages a common pool of spectrum and is responsible f...

Lexico-semantic collocations (LSCs) are a prominent type of multiword expressions. Over the last decade, the automatic compilation of LSCs from text corpora has been addressed in a significant number of works. However, very often, the output of an LSC-extraction program is a plain list of LSCs. Being useful as raw material for dictionary construction, plain lists of LSCs are of a rather limited...

Improvement of solid oxide fuel cells strongly relies on the development of cathode materials with high catalytic activity for the oxygen reduction reaction. Excellent activity was found for perovskite-type oxides such as La1-xSrxCoO3-δ (LSC), but performance degradation, probably caused by surface composition changes, hinders exploitation of the full potential of LSC. This study reveals that t...

INTRODUCTION AND AIMS We aim to compare clinical and surgical outcomes between minilaparoscopic sacrocolpopexy (MLSC) and conventional laparoscopic sacrocolpopexy (LSC). As far as we know, no comparative study exists between these two minimal invasive procedures to correct vaginal prolapse. DESIGN AND SETTING An observational and comparative study with 20 individuals submitted to vaginal vaul...

Cancer stem cells represent a novel therapeutic target. The major challenge in targeting leukemic stem cells (LSC) is finding therapies that largely spare normal hematopoietic stem cells (HSC) while eradicating quiescent LSCs. We present a mathematical model to predict how selective a therapy must be to ensure that enough HSCs survive when LSCs have been eradicated. Stem cell population size is...

In this work, a Monte Carlo ray-tracing model for the simulation and optimization of fiber Luminescent Solar Concentrator (LSC) based on stacked layers arrays is developed validated. The LSC efficiency improvements are compared against conventional planar LSC. We new to analyze performance different configurations bulk-doped fibers constituted by doped coating passive core. These analyzed also ...

The thermal neutron background at Laboratorio Subterráneo de Canfranc (LSC) has been determined using several 3He proportional counter detectors. Bare and Cd shielded counters were used in a series of long measurements. Pulse shape discrimination techniques applied to discriminate between gamma signals as well other intrinsic contributions. Montecarlo simulations allowed us estimate the sensiti...