The use of dichloroacetate (DCA) for treating patients with mitochondrial diseases is limited by the induction of peripheral neuropathy. The mechanisms of DCA-induced neuropathy are not known. Oral DCA treatment (50-500 mg/kg per day for up to 16 weeks) induced tactile allodynia in both juvenile and adult rats; concurrent thermal hypoalgesia developed at higher doses. Both juvenile and adult ra...

Bile acids are often refluxed into the lower oesophagus and are candidate carcinogens in the development of oesophageal adenocarcinoma. We show here that the secondary bile acid, deoxycholic acid (DCA), is the only one of the commonly refluxed bile acids tested here, to show genotoxicity, in terms of chromosome damage and mutation induction in the human p53 gene. This genotoxicity was apparent ...

B-chronic lymphocytic leukemia (B-CLL) patients harboring p53 mutations are invariably refractory to therapies based on purine analogues and have limited treatment options and poor survival. Having recently demonstrated that the mitochondria-targeting small molecule sodium dichloroacetate (DCA) exhibits anti-leukemic activity in p53wild-type B-CLL cells, the aim of this study was to evaluate th...

The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, there is continued interest in inhibitors of glycolysis as cancer therapeutics. One example is dichloroacetate (DCA), a pyruvate mimetic that stimulates oxidative phosphorylation through inhibition of pyruvate dehy...

The decrease in plasma lactate during dichloroacetate (DCA) treatment is attributed to stimulation of lactate oxidation. To determine whether DCA also inhibits lactate production, we measured glucose metabolism in muscles of fed and fasted rats incubated with DCA and insulin. DCA increased glucose-6-phosphate, an allosteric modifier of glycogen synthase, approximately 50% and increased muscle g...

مقولات ابزار ذهن ما برای شناخت حقایق اطراف است. بشر اشیای خارجی یا مفاهیم ناظر به آن‌ها را ذیل یکی از قرار داده است و فهم می‌کند. اما میزان صدق بر تمام واقعیات هستی هنوز درستی مشخص نیست. آنچه در آرای برخی فلاسفة مشاء دیده می‌شود‌این که پیرو آن انواعی آنها‌ایجاد می‌شود نقش تعیین کننده تعین نوعی موجودات دارند صرفاً طبقه بندی انسان نیستند. در‌این میان ملاصدرا دیدگاه متفاوتی آراء خود نشان می‌دهد محد...

Given a distributed coordination algorithm (DCA) for agents coupled by a network, which can be characterized by a stochastic matrix, we say that the DCA can be asynchronously implemented if the consensus property is preserved when the agents are activated to update their states according to their own clocks. This paper focuses on two central problems in asynchronous implementation of DCA: which...

[Ru(bpy)(3)](2+) (bpy = 2,2'-bipyridine) ions were entrapped into the cavities of two-dimensional anionic sheet-like coordination polymeric networks of [M(dca)(3)](-) (dca = dicyanamide; M = Mn(II) and Fe(II)). The prepared compounds, {[Ru(bpy)(3)][Mn(dca)(3)](2)}(n) (1) and {[Ru(bpy)(3)][Fe(dca)(3)](2)}(n) (2), were structurally characterized by X-ray single crystal analysis. The spectroscopic...

Two new dicyanamide bridged complexes [Mn(μ1,5-dca)2(salicyh)2]n (1) and {[Ni(μ1,5-dca)(TTA)](ClO4)}n (2) (dca = dicyanamide, ; salicyh = salicylic hydrazide; TTA = triethylenetetramine) have been synthesised and structurally characterised. Both the compounds 1 and 2 consist in 1-D coordination polymers. In 1 the manganese atoms are doubly bridged by μ1,5-dca ligands, whereas in 2 the nickel at...

زمینه و هدف: افزایش عوامل التهابی متعاقب چاقی از دلایل اصلی مرگ‌ومیر است. اگرچه نقش تمرینات ورزشی، محدودیت کالریک مکمل‌های ضداکسایشی در این گزارش شده است، اثر همزمان هر سه مداخله مورد توجه پژوهشگران زیادی ازاین‌رو هدف پژوهش حاضر بررسی هشت هفته تمرین تناوبی شدید، کالری مکمل اسپرولینا بر بافت قلب موش‌های صحرایی تحت رژیم غذای پرچرب بود.مواد روش‌ها: 45 سر موش نر چاق‌شده با غذایی (60 درصد چربی، 20 پ...