Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition, there are likely to be additional pathways that support the process. Here, we identify Annexin A2 as an autophagy modulator that regulates au...

Let A2(n) denote the quotient of the Siegel upper half space of degree two by ?2(n), the principal congruence subgroup of level n in Sp(4; Z). A2(n) is the moduli space of principally polarized abelian varieties of dimension two with a level n structure, and has a compacti-cation A2(n) rst constructed by Igusa. When n 3 this is a smooth projective algebraic variety of dimension three. In this w...

Resident mouse peritoneal macrophages have three phospholipase activities: a phospholipase A2 active at pH 4.5, a Ca2+-dependent phospholipase A2 active at pH 8.5 and a phosphatidylinositol-specific phospholipase C activity. When macrophages are exposed to zymosan in culture, the cellular activity of pH-4.5 phospholipase A2 is diminished in a manner dependent on zymosan concentration and time o...

This research includes synthesis of new derivatives benzimidazole , the compound (A1*) prepared by reaction o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then was ethyl chloroacetate and hydroxide to give ester (A2*). preparation hydrazide (A3*) (A2*) hydrazine hydrate (80%). we used prepare pyrazole (A4), then mannich basses (A4) different primary aromatic amines ...

Let X be an n–element finite set, 0 < k < n/2 an integer. Suppose that {A1, B1} and {A2, B2} are pairs of disjoint k-element subsets of X (that is, |A1| = |B1| = |A2| = |B2| = k,A1 ∩ B1 = ∅, A2 ∩ B2 = ∅). Define the distance of these pairs by d({A1, B1}, {A2, B2}) = min{|A1−A2|+ |B1−B2|, |A1−B2|+ |B1−A2|}. It is known ([2]) that this is really a distance on the space of such pairs and that the ...

Antibodies having light (L) chains encoded by the kappaII-A2 variable region gene segment predominate in the human response to the Haemophilus influenzae type b polysaccharide (Hib PS). To determine whether the closely related homologue of the A2 gene, the kappaII-A18 gene, has the potential to contribute to the repertoire, we examined Hib PS binding to a series of recombinant Fab fragments hav...

BACKGROUND Annexin A2 is a peripheral membrane protein that belongs to the annexin family of Ca(2+) and phospholipid-binding proteins. This protein, which plays a role in membrane organization and dynamics in particular along the endocytic pathway, exists as a heterotetrameric complex, consisting of two annexin A2 molecules bound via their N-termini to a dimer of p11/S100A10 light chains. The l...

Urea transporters UT-A2 and UT-B are expressed in epithelia of thin descending limb of Henle's loop and in descending vasa recta, respectively. To study their role and possible interaction in the context of the urine concentration mechanism, a UT-A2 and UT-B double knockout (UT-A2/B knockout) mouse model was generated by targeted deletion of the UT-A2 promoter in embryonic stem cells with UT-B ...

We have previously shown that recombinant interleukin 1 (IL-1) and recombinant tumour necrosis factor (TNF) synergistically stimulate phospholipase A2 release from mesangial cells. We now report that treatment of mesangial cells with the beta-agonist salbutamol, prostaglandin E2 (PGE2), cholera toxin or forskolin, which all activate adenylate cyclase, increased release of phospholipase A2 activ...

In the present paper, making use of Gegenbauer polynomials, we initiate and explore a new family J?(?,?,s,t,q;h) holomorphic bi-univalent functions which were defined in unit disk D associated with q-Srivastava–Attiya operator. We establish bounds for |a2| |a3|, where a2, a3 are initial Taylor–Maclaurin coefficients. For investigate Fekete-Szegö inequality, special cases consequences.