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conclusions decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than ptx. results the serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. the serum levels of il-6 were significantly decreased, in both groups, only at 6 mont...

The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing annually as the metabolic syndrome factors increase. This study aimed to analyze involvement periodontopathic bacteria in NASH-related HCC (NASH-HCC). Questionnaire investigation, periodontal examination, medical and specimen collection (saliva, mouth-rinsed water, peripheral blood) were p...

We consider full-truthful Nash implementation, which requires truth telling by each agent to be a Nash equilibrium of a direct revelationmechanism, and every Nash equilibrium outcome of the mechanism to be f optimal. We show that restricted monotonicity plus an auxiliary condition is necessary and sufficient for full-truthful Nash implementation, and that full-truthful Nash implementation is eq...

UNLABELLED Liver biopsy remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH). We have recently demonstrated that plasma cytokeratin 18 (CK-18) fragment levels correlate with the magnitude of hepatocyte apoptosis and independently predict the presence of NASH. The goal of this study was to validate the use of this biomarker for NASH diagnosis. The study was an ancillary s...

BACKGROUND Obesity as a worldwide health problem is associated with nonalcoholic steatohepatitis (NASH). Since severe liver injury may be present in asymptomatic obese patients and a definite diagnosis of nonalcoholic steatohepatitis can only be made after an invasive procedure of liver biopsy, there is a need for noninvasive methods to predict the probability of NASH. OBJECTIVES To investiga...

Nonalcoholic fatty liver disease is the most common chronic liver disease, which can progress to nonalcoholic steatohepatitis (NASH). Previous investigations demonstrated alterations in the expression and activity of hepatic drug transporters in NASH. Moreover, studies using rodent models of cholestasis suggest that compensatory changes in kidney transporter expression occur to facilitate renal...

Correspondence to: Professor A M Diehl, Duke University Medical Center, Box 3256, Snyderman/GSRB-1, 595 LaSalle St, Durham, NC 27710, USA; diehl004@ mc.duke.edu _________________________ ‘‘PRIMARY’’ NASH AND THE DYSMETABOLIC SYNDROME Histopathological characteristics distinguish steatohepatitis from other causes of chronic liver injury. For years, the main cause of steatohepatitis was thought t...