Purpose. To evaluate the relationship between corneal and conjunctival epithelium thickness and ocular surface clinical tests in dry eye disease (DED) patients. Patients and Methods. Fifty-four patients with DED and 32 control subjects were included. Each patient underwent an ocular surface evaluation using the ocular surface disease index (OSDI), tear film break-up time (TBUT), corneal and con...

This paper taught the performance of the proposed sensing models, namely, constant false alarm ratedynamic waveform detector (CFAR-DWD) are categorized as dynamic threshold (DT), two-stage (TS), and adaptive two-stage (ATS) detection for accurately detecting of the static-primary user (PU) signals, where the state of the PU signal not change during the sensing duration. Whereby it is carried ou...

The CD95 signaling pathway comprises proteins that contain one or two death effector domains (DED), such as FADD/Mort1 or caspase-8. Here we describe a novel 37 kDa protein, DEDD, that contains an N-terminal DED. DEDD is highly conserved between human and mouse (98. 7% identity) and is ubiquitously expressed. Overexpression of DEDD in 293T cells induced weak apoptosis, mainly through its DED by...

Background: Dry Eye Disease (DED) is a common ophthalmic condition resulting from dysfunction in the ocular surface, main lacrimal gland, meibomian glands, or connecting nerves. Objective: A group of local experts met to discuss challenges and establish consensus DED management across Middle East. Methods: modified Delphi method was used reach consensus, comprising two rounds survey face-to-fac...

Symptom Assessment DED patients may experience a variety of symptoms: discomfort, blurred vision, dryness, irritation, and, in some cases, just awareness of their eyes. These ocular surface symptoms are nonspecifi c and often not self-reported. To identify suspect DED and establish the need for further assessment, a good fi rst step is to ask patients how their eyes feel and what kind of sympto...

PURPOSE To determine the changes in dry eye disease (DED) severity and the percentage of cells expressing HLA-DR on the ocular surface following treatment with lubricant eyedrops containing polyethylene glycol and propylene glycol (PEG/PG) and the gelling agent hydroxypropyl guar (HP-Guar). PATIENTS AND METHODS Nineteen patients with DED used PEG/PG + HP-Guar eyedrops four times per day for 3...

The co-occurrence of multiple pathologies in the pelvic viscera in the same patient, such as, irritable bowel syndrome and interstitial cystitis, indicates the complexity of viscero-visceral interactions and the necessity to study these interactions under multiple pathological conditions. In the present study, the effect of distal colon irritation (DCI) on the urinary bladder interaction with d...

Dry eye disease (DED) is a clinically significant multifactorial disorder of the ocular surface and tear film as it results in ocular discomfort and visual impairment and predisposes the cornea to infections. It is important for the quality of life and tends to be a chronic disease. It is also common, as the prevalence is estimated between 5 % to 30 % and this increases with age. Therefore, it ...

Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to facilitate the optimal transmission of light. At the air-water interface, the tear film lipid layer (TFLL), a mixture of lipids and proteins, plays a key role in tear surface tension and is important for the physiological hydration of the ocular surface and for ocular homeostas...