Dominant optic atrophy (DOA) is the commonest form of inherited optic neuropathy. Although heterogeneous, a major locus has been mapped to chromosome 3q28 and the gene responsible, OPA1, was recently identified. We therefore screened a panel of 35 DOA patients for mutations in OPA1. This revealed 14 novel mutations and a further three known mutations, which together accounted for 20 of the 35 f...

UNLABELLED DEFINITION OF THE DISEASE: Dominant Optic Atrophy (DOA) is a neuro-ophthalmic condition characterized by a bilateral degeneration of the optic nerves, causing insidious visual loss, typically starting during the first decade of life. The disease affects primary the retinal ganglion cells (RGC) and their axons forming the optic nerve, which transfer the visual information from the pho...

An approach for joint direction of arrival (DOA) angle and frequency estimation a linear array is investigated in this paper. Specifically, we make the utmost autocorrelation cross-correlation information to propose an extended DOA-matrix (EDOAM) method. Subsequently, obtain auto-paired estimates by eigenvalues corresponding eigenvectors novel DOA matrix. Furthermore, proposed method surpasses ...

The effects of in ovo injection L-ascorbic acid (L-AA) on tissue L-AA concentrations, systemic inflammation, plasma mineral and tracheal histomorphology Ross 708 broilers subjected to elevated atmospheric ammonia (NH3) levels after hatch were investigated. four treatments included non-injected (control), saline-injected or saline containing 12 25 mg L-AA. applied at 17 days incubation by inject...

BACKGROUND Procedural sedation and analgesia (PSA) is used to attenuate the pain and distress that may otherwise be experienced during diagnostic and interventional medical or dental procedures. As the risk of adverse events increases with the depth of sedation induced, frequent monitoring of level of consciousness is recommended. Level of consciousness is usually monitored during PSA with clin...

| A simple general formula is derived under a Gaussian model for the asymptotic covariance of direction-of-arrival (DOA) estimators based on the covariance of the sensor array data. It is then established that the same formula remains valid for a wide class of statistical models for source signals. Hence, under mild assumptions, the asymp-totic performance of most high-resolution covariance-bas...

Hexagonal arrays are widely used in practice but have received less attention in the optimum array processing literature. In this paper, we show how unitary ESPRIT can be applied to hexagonal arrays for direction-of-arrival (DOA) estimation. The resulting estimates exhibit good threshold behavior, and are close to the Cramer-Rao bound above threshold. We also show how to use spatial smoothing i...