background and objectives:alzheimer’s disease (ad) is a neurodegenerative disorder. nowadays, many investigations are performed to find new drugs for ad and medicinal plants are considered as one of the most important sources for developing new drugs. according to the role of oxidant agents and acetylcholinesterase enzyme (ache) in ad, plants with antioxidant and ache inhibition properties coul...

background and objectives:lallemantia iberica (lamiaceae) is a medicinal plant distributed in different parts of iran. this research, has evaluated the phytochemical constituents and antioxidant activity of the aerial parts of the plant. methods: different chromatographic methods such as column chromatographies using silica gel (normal and reversed phases), sephadex lh-20 and hplc were used for...

A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavon...

Nineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory effect was tested in acute rat experimental inflammation by measuring the acute phase bone marrow response, the phagocytic capacity and the s...

We used DPPH scavenging assays to study the antioxidant activity of three native Polish species of blackberry leaves (Rubus kuleszae Ziel., R. fabrimontanus (Sprib.) Sprib. and R. capitulatus Utsch.). All the studied extracts (methanolic, water, methanolic-water) showed high DPPH free radical scavenging activity (IC50 450.0–186.0 μg/ml). The most effective of the studied species was Rubus kules...

Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demons...

Vasicine (1) was isolated from the ethanolic extract of Adhatoda vasica Nees (Acanthaceae) and the structure was confirmed using spectroscopic techniques. Acetylcholine esterase, trypsin, DPPH inhibition potential and FRAP assay were carried out using in vitro models. The results showed 38.4 ± 1.2% and 37.4 ± 1.1% activity in acetylcholine and trypsin inhibition assays respectively. The compoun...

Kinetics and stoichiometric measurements based on the reactions of stable free radicals are among the most employed procedures in the evaluation of antioxidant activities of pure compounds and complex mixtures. In the present work it is shown that initial rates of diphenyl-picryl hydrazyl (DPPH) consumption elicited by cinnamic acid derivatives are closely related to their reactivity towards pe...

Protein isolates of pumpkin (Cucurbita pepo L) seeds were hydrolyzed by acid protease to prepare antioxidative peptides. The hydrolysis conditions were optimized through Box-Behnken experimental design combined with response surface method (RSM). The second-order model, developed for the DPPH radical scavenging activity of pumpkin seed hydrolysates, showed good fit with the experiment data with...