BACKGROUND Inherited epidermolysis bullosa (EB) is a group of skin diseases characterized by blistering of the skin and mucous membranes.There are four major types of EB (EB simplex, junctional EB, dystrophic EB and Kindler syndrome) caused by different gene mutations. Dystrophic EB is derived from mutations in the type VII collagen gene (COL7A1), encoding a protein which is the predominant com...

BACKGROUND To prevent inappropriate empiric antibiotic treatment in patients with bacteremia caused by third-generation cephalosporin (3GC)-resistant Enterobacteriaceae (3GC-R EB), Dutch guidelines recommend β-lactam and aminoglycoside combination therapy or carbapenem monotherapy in patients with prior 3GC-R EB colonization and/or recent cephalosporin or fluoroquinolone usage. Positive predict...

Although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism(s) by which estrogens can acutely change seizure parameters including after discharge and seizure durationremains to be determined. In the present study, we examined the role of NMDA (N-methyl-D-aspartate), non-NMDA andestrogen receptors in estradiol benzoate(EB) effects...

Epidermolysis bullosa (EB) is a diverse group of disorders that have as a common feature blister formation with tissue separation occurring at variable depths in the skin and/or mucosa depending on the specific EB type. There may be marked oral involvement, potentially creating devastating alterations in the soft and hard tissues. Oral tissue fragility and blistering is common to all EB types. ...

AIM To assess proliferative and apoptotic potential of the seminiferous epithelium cells in relation to Sertoli cell maturation in newborn rats under the influence of estradiol, follicle stimulating hormone (FSH) or both agents given together. METHODS From postnatal day (PND) 5 to 15 male rats were daily injected with 12.5 microg of 17beta-estradiol benzoate (EB) or 7.5 IU of human purified F...

This paper examines ethnicity among highly skilled immigrants to the United States. The paper focuses on five classic components of ethnicity - country of birth, race, skin color, language, and religion - among persons admitted to legal permanent residence in the United States in 2003 in the three main employment categories (EB-1, EB-2, and EB-3), using data collected in the U.S. New Immigrant ...

A replicated 4 x 4 Latin square digestion trial was conducted to determine the effect of electrolyte balance (EB = Na + K - Cl meq/kg of the diet) on apparent nutrient digestibilities in pigs fitted with ileal T-cannulas. Experimental diets were composed of corn and soybean meal with dietary EB altered by the substitution of CaCl2 for CaCO3, or NaHCO3 for corn and soybean meal. Electrolyte bala...

We have shown previously that glycogen synthase kinase-3 (GSK-3 ), cyclin-dependent kinase 5, and c-Jun NH2-terminal kinase become overactivated and hyperphosphorylate in heat-shocked female rats. This hyperphosphorylation of is estrogen-independent, prevented by androgens, and similar to Alzheimer’s disease. In this study, ovariectomized (OVX) Sprague-Dawley rats (n 75) received daily injectio...

OBJECTIVE To assess the effect of equilibration time on the DNA integrity of vitrified-warmed mouse blastocysts. DESIGN Prospective in vitro study. SETTING Embryology research laboratory. INTERVENTION(S) Mouse nonexpanded blastocysts (NEB) (n = 54) and expanded blastocysts (EB) (n = 56) were vitrified using cryotips. Blastocysts were vitrified using a two-step media protocol, with a first...