Purpose Existing literature is limited in its ability to consider start-ups as a knowledge broker trigger innovation supply chain ecosystem (SCE). In traditional SCE, are relatively isolated, leading structural holes that limit sharing among members. This paper aims overcome limitation and build frameworks help illustrate the interaction between management sharing, start-up an from perspective....

Postpartum diseases of uterus represent a foremost predicament in cattle farms affecting reproductive efficiency. (PP) uterine include metritis, endometritis and subclinical (SCE). Barring SCE, all other project the clinical signs. Diagnosis SCE at early stage PP has been challenging task for many veterinarians. The present study aimed to validate correlate proficiency transitional changes cerv...

BACKGROUND Sister chromatid exchange (SCE) is a widely used sensitive cytogenetic biomarker of exposure to genotoxic and cancerogenic agents. Results of human monitoring studies and cytogenetic damage have revealed that biological effects of genotoxic exposures are influenced by confounding factors related to life-style. Vegetable and fruit consumption may play a role, but available results are...

A sugar cane extract (SCE) has been found to have an immunostimulating effect in several animals. Lipopolysaccharide (LPS) is known to induce endotoxin shock via the production of inflammatory modulators such as tumor necrosis factor (TNF)-alpha and nitric oxide (NO). We examined in the present study the effects of SCE on the TNF-alpha and NO production in LPS-stimulated mice peritoneal cells a...

Diabetes is a major global health issue and the number of individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D) increases annually across multiple populations. Research to develop a cure must overcome multiple immune dysfunctions and the shortage of pancreatic islet β cells, but these challenges have proven intractable despite intensive research effort more than the past decades. Ste...

This paper describes a method for scheduling large-scale hydrothermal power systems based on the shuffled complex evolution (SCE-UA) method. A multi-reservoir cascaded hydro-electric system with a non-linear relationship between water discharge rate, net head and power generation is considered. The water transport delay between connected reservoirs is also taken into account. SCE-UA is a succes...

BACKGROUND Studying relative anaerobic and aerobic metabolism contributions to total energy release during exercise may be valuable in understanding exercise energetic demands and the energetic adaptations that occur in response to acute or chronic exercise in obese adults. The aim of the present study is to evaluate the effects of 6 weeks of high-intensity training (HIT) on relative anaerobic ...

BACKGROUND Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that causes a deficit of pancreatic islet β cells. The complexities of overcoming autoimmunity in T1D have contributed to the challenges the research community faces when devising successful treatments with conventional immune therapies. Overcoming autoimmune T cell memory represents one of the key hurdles. METHODS In th...

Although phosphoramide mustard (PM) is generally recognized as being the most genotoxic metabolite of cyclophosphamide (CP), the contribution of acrolein to the cytogenetic toxicity of CP is unclear. Besides covalently binding to DNA, acrolein can inactivate critical proteins necessary for replicative DNA synthesis, RNA transcription, cell membrane integrity, and metabolism of xenobiotic and en...