Tetrahydrobiopterin (BH4) is an essential cofactor for the production of nitric oxide (NO) and supplementation with BH4 improves NO-dependent vasodilation. NO also reduces sympathetic vasoconstrictor responsiveness in resting and contracting skeletal muscle. Thus, we hypothesized that supplementation with BH4 would blunt sympathetic vasoconstrictor responsiveness in resting and contracting skel...

Lung function studies in middle-aged subjects predict cardiovascular disease mortality. We studied whether greater loss of forced vital capacity (FVC) early in life predicted incident hypertension. The sample was 3205 black and white men and women in the Coronary Artery Risk Development in Young Adults Study examined between 1985 and 1986 (Coronary Artery Risk Development in Young Adults year 0...

BACKGROUND In the context that accurate measurement of FVC is important in diagnosing airflow obstruction and in assessing restriction, strategies to achieve reliable and accurate FVC measurement have drawn much attention. OBJECTIVES Because the rate of achieving end-of-test criteria during spirometry has been shown to be low, with resultant under-recording of the FVC, the current study propo...

BACKGROUND We aimed to investigate the effects of spinal immobilization devices on pulmonary functions. METHODS This study was a cross-over trial in healthy volunteer subjects; 60 volunteers were included. We performed a full spirometry in the supine position, and forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC were recorded in all subjects. Then, Phila...

The partial effective times of the expiratory spirogram were calculated in 80 normal non-smoking subjects aged from 20 to 69 years and in 30 patients aged from 30 to 58 years with chronic bronchitis. Of these patients, 28 had a normal FEV1/FVC ratio, while the other two had a low ratio. Partial effective times were calculated for 10% segments of the expired FVC from total lung capacity (0% FVC)...

Fractional vegetation cover (FVC) is one of the most critical parameters in monitoring vegetation status. Accurate estimates of FVC are crucial to the use in land surface models. The dimidiate pixel model is the most widely used method for retrieval of FVC. The normalized difference vegetation index (NDVI) of bare soil endmember (NDVIsoil) is usually assumed to be invariant without taking into ...

BACKGROUND Forced expiratory volume in 6 s (FEV6) and FEV1/FEV6 ratio have traditionally been used as a surrogate for forced vital capacity (FVC) and FEV1/FVC in the assessment of spirometric lung function in nonpregnant subjects. However, the existence of this relationship during pregnancy is yet to be ascertained. AIM The aim of this study was to determine if FEV6 and FEV1/FEV6 can effectiv...

BACKGROUND A higher slow vital capacity (VC) compared with forced vital capacity (FVC) indicates small airway collapse and air trapping. We hypothesized that a larger difference between VC and FVC (VC-FVC) would predict impaired exercise capacity in patients with chronic obstructive pulmonary disease (COPD). METHODS Pulmonary function and incremental cardiopulmonary exercise responses were as...