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With the evolution of an API library, its documentation also evolves. The evolution of API documentation is common knowledge for programmers and library developers, but not in a quantitative form. Without such quantitative knowledge, programmers may neglect important revisions of API documentation, and library developers may not effectively improve API documentation based on its revision histor...

There are many reports on the appearance of a typical isoenzyme of alkaline phosphatase (EC 3.1.3.1; API)2 in serum of patients suffering from biliary obstruction. According to the characteristics observed in various studies, this API has variouslybeen termed “high molecular weight” (1), “origin,” “stationary,” “particulate” (2), “bile,” “cholestatic,” “pathological biliary” (3, 4), and “koinoz...

Most applications need to invoke some Application Programming Interfaces (APIs), e.g. JDK (Java Development Kit) API. When invoking those APIs, applications must follow some API constraints. Violation of these constraints will lead to some severe program defects. To detect this kind of defects, lots of static and dynamic approaches are explored, using formally described API constraints. While m...

API-1 (pyrido[2,3-d]pyrimidines) is a novel small-molecule inhibitor of Akt, which acts by binding to Akt and preventing its membrane translocation and has promising preclinical antitumor activity. In this study, we reveal a novel function of API-1 in regulation of cellular FLICE-inhibitory protein (c-FLIP) levels and TRAIL-induced apoptosis, independent of Akt inhibition. API-1 effectively ind...

Malignant mesothelioma (MM) is a tumor arising from mesothelium. MM patients' survival is poor. The polyphenol 4',5,7,-trihydroxyflavone Apigenin (API) is a "multifunctional drug". Several studies have demonstrated API anti-tumoral effects. However, little is known on the in vitro and in vivo anti-tumoral effects of API in MM. Thus, we analyzed the in vitro effects of API on cell proliferation,...