Leucine-rich α2-glycoprotein (LRG) is an approximately 50-kDa glycoprotein that has been found to be elevated in the sera of patients with several types of cancer. LRG directly binds to transforming growth factor beta 1 (TGFβ1) and modulates TGFβ1 signaling in endothelial cells; however, the precise function of LRG in cancer remains unclear. This study aimed to investigate the role of LRG in ca...

Recent studies have shown that embedded DRAM (eDRAM) is a promising approach for 3D stacked lastlevel caches (LLCs) rather than SRAM due to its advantages over SRAM; (i) eDRAM occupies less area than SRAM due to its smaller bit cell size; and (ii) eDRAM has much less leakage power and access energy than SRAM, since it has much smaller number of transistors than SRAM. However, different from SRA...

We have demonstrated that ouabain causes dose- and time-dependent decreases both in 86Rb+ uptake and plasmalemmal Na/K-ATPase content of LLC-PK1 cells, which is related to ouabain-induced endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells through a clathrin-dependent mechanism. GRP78/BiP is a resident protein of the endoplasmic reticulum (ER) and acts as a molecular chaperone. Recently, s...

Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and an ancillary drug in tumor treatment, enhances the antitumor effects of cisplatin on Lewis lung cancer (LLC) cells. Methods. LLC-bearing mice were daily intraperitoneally injected with various doses of cisplatin, Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were...

1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule that downregulates survivin and exhibits potent antitumor activity, is hydrophilic and cationic. Although previous studies have shown that influx transporters play important roles in the uptake of YM155 into hepatocytes and possibly into cance...

IMPORTANCE In recent years, with the advent of 3-dimensional (3D) imaging techniques, it has become possible to objectively measure rhinoplasty results. However, few studies have used 3D imaging software to assess postoperative rhinoplasty results of the nasal tip. OBJECTIVE To analyze nasal tip volumes of patients with bulbous tips and measure postoperative nasal tip volume changes in patien...

Extracellular ATP affects a wide variety of cells via purinergic membrane receptors. One class of purinergic receptors, P2X, consists of ATP-gated, calcium-permeable, cation-selective channels. We performed whole cell patch-clamp studies, intracellular calcium concentration ([Ca2+]i) measurements, and reverse transcription-polymerase chain reaction (RT-PCR) to determine whether P2X receptors ar...

Upregulation of ubiquitin ligase atrogin1/MAFbx and muscle wasting are hallmarks of cancer cachexia; however, the underlying mechanism is undefined. Here, we describe a novel signalling pathway through which Lewis lung carcinoma (LLC) induces atrogin1/MAFbx upregulation and muscle wasting. C2C12 myotubes treated with LLC-conditioned medium (LCM) rapidly activates p38 MAPK and AKT while inactiva...

Luminescent materials from europium β-diketonate complex in ionic liquids (ILs) could achieve enhanced luminescence efficiencies and photostabilities. However, the question of how to provide a feasible and environmentally-friendly way to distribute these lanthanide complexes uniformly and stably within IL-based matrix remains a significant challenge. Here, a soft luminescent material from IL-me...

Philippe Vanparys ALTOXICON BVBA (Vosselaar, Belgium) Leonard Schechtman Innovative Toxicology Consulting LLC (Lake Worth, Florida, USA) Marilyn Aardema Marilyn J. Aardema Consulting LLC (Fairfield, Ohio, USA) Makoto Hayashi Biosafety Research Center, Foods, Drugs and Pesticides (Shizuoka, Japan) Sebastian Hoffmann she consulting + services (Köln, Germany) Laura Gribaldo ECVAM (Ispra, Italy) Ra...