Cutaneous malignant melanoma (CMM), already known for its highly aggressive behavior and resistance to conventional therapy, has evolved into a health crisis by virtue of a dramatic elevation in incidence. The underlying genetic basis for CMM, as well as the fundamental role for UV radiation in its etiology, is now widely accepted. However, the only bona fide genetic locus to emerge from extens...

Knowledge management is used as underlying theory to develop a set of key process areas for a supplement to the CMM in small or medium sized enterprises (SME) that develop software. These processes involve a focus on managing knowledge capability rather than traditional project management. A longitudinal case study provides evidence that current practices have already established the feasibilit...

AIM To prospectively determine the prevalence of germline CDKN2A mutations in the Slovenian cutaneous malignant melanoma (CMM) families. METHODS From January 2001 till the end of 2003 we prospectively screened 19 individuals from 11 CMM families, as well as 3 children with CMM aged from 6 to 13 years, with a negative family history. RESULTS Five distinct mutations were detected in 5 out of ...

The Capability Maturity ModelSM for Software developed by the Software Engineering Institute has had a major influence on software process and quality improvement around the world. Although the CMM has been widely adopted, there remain many misunderstandings about how to use it effectively for businessdriven software process improvement, particularly for small organizations and small projects. ...

This article provides an overview on the regulations of Chinese medicinal materials (CMMs) in various countries and regions. Harmonization of CMM monographs would provide standards for the quality control of CMM products and play an important role in the modernization and globalization of Chinese medicine. A harmonized regulatory system would improve the quality of CMMs thereby ensuring the saf...

Department of Zoology, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa (CMM-B, DSJ, MCS) Division of Chemical Pathology, University of Cape Town Medical School, Observatory, 7925, South Africa (CMM-B, EHH) Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa (GE) Present addres...

The Capability Maturity Model (CMM) for Software is a development framework that describes the key elements for an effective software process. Cleanroom software engineering (CSE) is a managerial and engineering process for the development of high quality software with certified reliability. The combination of CMM management and organizational capabilities and the judicious application of Clean...