According to the US Patent Act, “Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title” (1 ). The courts have construed this statement as covering “anything under the sun made by man” (2 ). Although this language is ...

to damaged tissues and organs. In other words, regenerative medicine is the ‘process of replacing or regenerating human cells, tissues or organs to restore or establish normal function’ [4, 5] . It includes a group of biomedical approaches to clinical therapies that may involve the use of stem cells. Examples include: the injection of stem cells or progenitor cells (cell therapies), the inducti...

Myriad signals such as growth factors, cytokines, growth inhibitors, hormones, ions, extracellular matrix, and the resident hepatic cells are involved in the regulation of hepatic regeneration. These regulatory factors ultimately mediate changes in gene expression, a critical step in this well-orchestrated restorative process.

Talk of safety culture has emerged as a common trope in contemporary scholarship and popular media as an explanation for accidents and as a recipe for improvement in complex sociotechnical systems. Three conceptions of culture appear in talk about safety: culture as causal attitude, culture as engineered organization, and culture as emergent and indeterminate. If we understand culture as sociol...

We present two high-resolution local models for the crustal magnetic field of the Martian south polar region. Models SP130 and SP130M were derived from three-component measurements made by Mars Global Surveyor at nighttime and at low altitude (<200 km). The availability area for these data covers the annulus between latitudes −76∘ and −87∘ and contains a strongly magnetized region (southern par...