Synthetic agonists of Toll-like receptor 9 (TLR9), a class of agents that induce specific immune response, exhibit antitumor activity and are currently being investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth and angiogenesis are still incompletely understood. We recently discovered that a synthetic agonist of TLR9, immune modulatory oligonucleotide (IMO),...

The complex and proprietary nature of geospatial data makes them almost non-sharable among large user community. GIS interoperability is necessary for realizing a successful spatial data infrastructure. With the advancements of web service technology, GIS interoperability has made a paradigm shift – from monolithic GIS providers to distributed geospatial services. The applicability of web servi...

In many real-world application problems, the availability of data labels for supervised learning is rather limited and incompletely labeled datasets are commonplace in some of the currently most active areas of research. A manifold learning model, namely Generative Topographic Mapping (GTM), is the basis of the methods developed in the thesis reported in this paper. A variant of GTM that uses a...

The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene ex...

In the present world scenario, everybody is on the lookout for suitable housing options, each having different needs (e.g., the elderly are looking for safe, quiet neighbourhood, while students are looking for affordable apartments close to the university/school). For e.g., Craigslist currently does not have a map version, making the process of apartment searching a very long and laborious proc...

The existence of various geo-location applications and their accuracy requirements enhance the necessities for suitable processing techniques to solve the indoor geo-location problems. Since, Impulse Radio Ultra-Wideband (IR-UWB) signals have very short duration pulses; they can provide very accurate ranging and geo-location capability in short range indoor radio propagation environments. Our r...

The quay crane scheduling problem (QCSP) determines the handling sequence of tasks at ship bays by a set of cranes assigned to a container vessel such that the vessel’s service time is minimized. A number of heuristics or metaheuristics have been proposed to obtain the near-optimal solutions to overcome the NP-hardness of the problem. In this article, the idea of generalized extremal optimizati...

The quality and life of pavement is greatly affected by the type of sub-grade, sub base and base course materials. The most important of these are the type and quality of sub-grade soil. But in India most of the flexible pavements are need to be constructed over weak and problematic sub-grade. The California bearing ratio (CBR) of these sub-grade have very low, it needs to more thickness of pav...

The recent advances in geo-informatics have been opening new opportunities in earthquake early warning and emergency management issues. In the last years, the geo-scientific community has recognized the added value of a geo-analytic approach in complex decision making processes for critical situations due to disastrous natural events such as earthquakes. In fact, recently, GIS-based solutions a...