Acquired hemophilia A (AHA) is a rare disorder that results from the presence of autoantibodies against the clotting factor VIII (FVIII) causing hemorrhagic disorders. This entity is mostly associated with autoimmune diseases, pregnancy, the postpartum period, drugs and malignancy. Among the solid cancers, prostate neoplasm is the most common cause of AHA. The management of AHA involves the con...

Siderophores are microbial produced low molecular weight iron chelators and strongly bind to hard Lewis acids. The siderophore desferrioxamine B (DFO) has hydroxamate functional groups, similar to acetohydroxamic acid (AHA), a ligand that is proposed for actinide complexation in advanced separations. In the proposed separation involving AHA, the exact role of the complex in the extraction behav...

The major takeaway from 2022 Heart Failure guidelines (AHA/ACC/HFSA) was the 4-pillar concept of use beta-blockers, RAAS inhibition (preferably ARNI), mineralocorticoid antagonist, and SGLT2 inhibitors (irrespective diabetes) for HFrEF. recommendations HFpEF HF mildly reduced EF are less robust. Some important heart failure trials presented every year at ACC, AHA, ESC, TCT, which can impact our...

Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0b013e31829b2be6 †Deceased. The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are re...

Stimulation of G protein– or tyrosine kinase–coupled receptors regulates cell proliferation through intracellular Ca ([Ca]i) signaling. In A7r5 cells, we confirmed that inositol 1,4,5-trisphosphate (IP3) mediates vasopressin (VP)-evoked Ca release from intracellular stores and showed that types 1 (IP3R1) and 3 (IP3R3) IP3 receptors were expressed. Using antisera selective for IP3R1 or IP3R3 and...

After many years of hypertext research, the Dexter model was defined [7] to capture the features of most existing hypertext systems in a single, formal reference model. Likewise, the AHAM model [5] (based on Dexter) describes most features that are found in adaptive hypermedia systems (ahs). In the AHA! project funded by the NLnet Foundation we are extending the simple AHA system [4, 6] with th...

Aging is the main risk factor for coronary artery disease. One characteristic of aging coronary arteries is their enhanced contractile responses to endothelial vasoconstricting factors, which increase the risk of coronary vasospasm in older people. Because large-conductance voltageand Ca-activated K channels (MaxiK) are key regulators of vascular tone, we explored the possibility that this clas...

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The American Heart Association (AHA) has recommended a 12element questionnaire for pre-participation screening of athletes, in order to reduce and hopefully prevent sudden cardiac death in young athletes. This screening procedure is widely used throughout the United States, but its efficacy for discriminating Normal from Non-normal heart condition is unclear. As part of a larger study on cardio...

Adaptive hypermedia systems (AHS) have typically been geared towards one specific application or application area, in most cases related to education. The AHA (Adaptive Hypermedia Architecture) system is a Web-based adaptive hypermedia system specifically intended to serve many different purposes. As such AHA must be able to perform adaptation that is based on the user’s browsing actions, regar...