Established in 1995, the UNU/Institute of Advanced studies (UNU/IAS) is an advanced research and education institution with a flexible and multi-thematic programme orientation concerned with the interactions of social and natural systems. For the initial years, the UNU/IAS programme is directed at sustainable development issues. To this end, the UNU/IAS is currently active in the following rele...

BACKGROUND Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are evident in adulthood. There is considerable interest in identifying the mole...

BACKGROUND Chronic inflammation plays a key role in the pathogenesis of intracranial aneurysms (IAs). DPP-4 (dipeptidyl peptidase-4) inhibitors have anti-inflammatory effects, including suppressing macrophage infiltration, in various inflammatory models. We examined whether a DPP-4 inhibitor, anagliptin, could suppress the growth of IAs in a rodent aneurysm model. METHODS AND RESULTS IAs were...

Instantaneous angular speed (IAS)-based condition monitoring is an area in which significant progress has been achieved over the recent years. This condition monitoring technique is less known compared to the existing conventional methods. This paper presents model-predicted simulation and experimental results of broken rotor bar faults in a threephase induction motor using IAS variations. The ...

BACKGROUND The Illness Attitude Scales (IAS), designed by Kellner in 1986, assesses fears, beliefs, and attitudes associated with hypochondriasis and abnormal illness behaviour. However, its factor structure is, especially for translations of the IAS, not sufficiently explored. Thus, the present Study aimed to analyse the factor structure of the IAS in a German student and a patient population ...

The effects of Reynolds and Womersley numbers on the hemodynamics of two simplified intracranial aneurysms (IAs), that is, sidewall and bifurcation IAs, and a patient-specific IA are investigated using computational fluid dynamics. For this purpose, we carried out three numerical experiments for each IA with various Reynolds (Re = 145.45 to 378.79) and Womersley (Wo = 7.4 to 9.96) numbers. Alth...

Autosomal dominant polycystic kidney disease (ADPKD) belongs to the most common genetic disorders, with approximately 12.5 million individuals involved worldwide. The disease is a well-known risk factor for intracranial aneurysms (IAs). The rupture of an IA is associated with a high risk of serious complications or death, yet universal screening for IAs in ADPKD remains controversial. It is mai...

OBJECTIVES To evaluate anal sphincter anatomy using three-dimensional ultrasonography (3-DAUS) in incontinent women with vaginal delivery, correlate anatomical findings with symptoms of fecal incontinence and determine the effect of vaginal delivery on anal canal anatomy and function. METHODS Female with fecal incontinence and vaginal delivery were assessed with Wexner's score, manometry, and...