Camptothecin (CN) is active against several experimental tumors and has also been studied clinically. We report here the effect of CN on LI210 cells and asynchronous and synchronous DON cells in culture. CN was toxic both to LI210 cells (0.06 ¿ig/ml,2-hr exposure) and DON cells (0.15 Mg/ml, 1-hr exposure), and it inhibited DNA and RNA synthesis more than it inhibited protein synthesis. CN was ...

OBJECTIVE The aim of this study was to evaluate the effect of cardiac rhythm on the echocardiographic mitral valve area (MVA) and transmitral gradient calculation in relation to net atrioventricular compliance (Cn). METHODS Patients (n=22) with mild or moderate pure rheumatic mitral stenosis (MS) (MVA <2 cm2 and MVA >1 cm2) and atrial fibrillation (AF) were evaluated. All patients underwent t...

The Soil Conservation Service Curve Number (SCS-CN) approach is widely used as a simple method for predicting direct runoff volume for a given rainfall event. The CN parameter values corresponding to various soil, land cover, and land management conditions can be selected from tables, but it is preferable to estimate the CN value from measured rainfall-runoff data if available. However, previou...

Let φ : Cn×Cn → C, φ((x1, ..., xn), (y1, ..., yn)) = (x1−y1)+ ...+ (xn − yn). We say that f : Rn → Cn preserves distance d ≥ 0 if for each x, y ∈ Rn φ(x, y) = d implies φ(f(x), f(y)) = d. We prove that if x, y ∈ Rn (n ≥ 3) and |x − y| = ( √ 2 + 2/n)k · (2/n)l (k, l are nonnegative integers) then there exists a finite set {x, y} ⊆ Sxy ⊆ Rn such that each unit-distance preserving mapping from Sxy...

Reaction of Mo(2)Cl(4)(dppm)(2) (dppm = bis(diphenylphosphino)methane) with 6 equiv of [n-Bu(4)N][CN] or [Et(4)N][CN] in dichloromethane yields [n-Bu(4)N](2)[Mo(2)(CN)(6)(dppm)(2)] (1) and [Et(4)N](2)[Mo(2)(CN)(6)(dppm)(2)] (2), respectively. The corresponding one- and two-electron oxidation products [n-Bu(4)N][Mo(2)(CN)(6)(dppm)(2)] (3) and Mo(2)(CN)(6)(dppm)(2) (4)were prepared by reactions o...

I mean... You know... We study certain analytic properties of the ordered and unordered configuration spaces Cn o (X) = {(q1, ..., qn) ∈ X | qi 6= qj ∀ i 6= j} and Cn(X) = {Q ⊂ X | #Q = n} of simply connected algebraic curves X = C and X = CP. For n ≥ 3 the braid group Bn(X) = π1(C(X)) of the curve X is non-abelian. A map F : Cn(X) → Ck(X) is called cyclic if the subgroup F∗(π1(C(X))) ⊂ π1(C(X)...

The rotational spectrum of the molecular negative ion CN(-) has been detected in the laboratory at high resolution. The four lowest transitions were observed in a low pressure glow discharge through C(2)N(2) and N(2). Conclusive evidence for the identification was provided by well-resolved nitrogen quadrupole hyperfine structure in the lowest rotational transition, and a measurable Doppler shif...