BACKGROUND AND PURPOSE Targeting the prostaglandin I2 prostanoid (IP) receptor to reduce stroke injury has been hindered by the lack of selective drugs. MRE-269 is the active metabolite of selexipag showing a high selectivity toward the IP receptor. Selexipag has been recently approved for clinical use in pulmonary hypertension. We hypothesized that postischemic treatment with MRE-269 provides ...

We present COBS — a model of a concurrent object-based computational system with handshakes as elementary actions of inter-process communication. Processes are considered to be partial views of the system. Their communication by asynchronous message passing and variable sharing is modeled by elementary processes on the same abstraction level. The same acts of computation and communication can b...

Molecular hybridization by the Northern blot technique in combina t ion with 12SI-labeled PSTV (+) RNA and S2P-labeled PSTV cDNA as probes has been applied to d e t e c t v i r o i d s p e c i f i c s e q u e n c e s in h e a l t h y and v i r o i d ( P S T V ) i n f e c t e d t o m a t o plants . Conditions are described which allow d i f f e r e n t i a t i o n of (+) and (-) viroid sequences...

Forkhead in rhabdomyosarcoma (FKHR) is a transcription factor that has been implicated in the control of gene expression by insulin, as well as the regulation of apoptosis by survival factors. These signals trigger the protein kinase B (PKB)-catalysed phosphorylation of FKHR at three residues (Thr(24), Ser(256) and Ser(319)) by a phosphoinositide 3-kinase-dependent pathway that results in the n...