the maintenance of the endangered caspian brown trout salmo trutta caspius populations in iran depends on its artificial breeding. there is no information on how current hatchery breeding protocol influences effective population size of breeders (ne), which is a critical parameter to maintain genetic diversity in future generations. the current hatchery protocol (chp) was comparatively evaluate...

The short and long forms of prolactin receptor (PRL-R) mRNA have been detected in the female rat brain. The present study aimed to investigate: (1) if the PRL-R mRNA is expressed in the male rat brain; (2) if expression levels in the female brain vary during the estrous cycle. All animals were sacrificed between 12:00 and 14:00 h. Radioactive RNase protection assay was used to measure mRNA leve...

To determine the histological reaction to, and the rate of absorption of, different pure crystalline lipids from the aortic subintimal space, cholesterol (Ch), cholesteryl palmitate (ChP), glyceryl tripalmitate (TP), palmitic acid (PA), and dipalmitoyl lecithin (DPL) were implanted in the inner media of the thoracic aorta of 37 dogs. Tiny crystalline rods were fabricated averaging 0.29 mm in di...

BACKGROUND In the literature the need for relevance in medical education and training has been stressed. In the last 40 years medical schools have been challenged to train doctors competent to respond to community health needs. In the mid-90s the University of Geneva Faculty of Medicine introduced an integrated medical curriculum. In this initiative a particular emphasis was put in introducing ...

7 The UK whole-wheat bioethanol and straw and DDGS based combined heat and power 8 (CHP) generation systems were assessed for environmental sustainability using a range of 9 impact categories or characterisations (IC): cumulative primary fossil energy (CPE), land use, 10 life cycle global warming potential over 100 years (GWP100), acidification potential (AP), 11 eutrophication potential (EP) a...

Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis in childhood, associated either with nonmalignant conditions or with subcutaneous panniculitis-like T-cell lymphoma (SPTCL), and often also associated with macrophage activation syndrome (MAS). Discriminating between these 2 conditions is therapeutically important because nonmalignant CHP often improves under cyclosporine and pred...

BACKGROUND A variety of N-glycans attached to protein are known to involve in many important biological functions. Endoplasmic reticulum (ER) and Golgi localized enzymes are responsible to this template-independent glycan synthesis resulting glycoforms at each asparagine residues. The regulation mechanism such glycan synthesis remains largely unknown. METHODOLOGY/PRINCIPAL FINDINGS In order t...

A phase I+II clinical trial of vaccination with MAGE-A4 protein complexed with cholesteryl pullulan melanoma antigen gene-A4 nanogel (CHP-MAGE-A4) is currently underway in patients with MAGE-A4-expressing cancer. In the present study, the primary phase I endpoint was to test the safety of the administration of 300 µg CHP-MAGE-A4 with and without OK-432. Another aim of the study was to clarify t...

In the last decade, voluntary environmental programs have increased considerably in scope. A novel use of these programs is to di¤use new technology in industry as means to improving their environmental outcomes. This paper tests whether the US Environmental Protection Agency’s Combined Heat-and-Power Partnership has encouraged the installation of CHP applications since its start in 2001. Two h...

Neuroblastoma (NBL) and medulloblastoma (MBL) are tumors of the neuroectoderm that occur in children. NBL and MBL express Trk family tyrosine kinase receptors, which regulate growth, differentiation, and cell death. CEP-751 (KT-6587), an indolocarbazole derivative, is an inhibitor of Trk family tyrosine kinases at nanomolar concentrations. This study was designed to determine the effect of CEP-...