The mammalian hippocampus harbours neural circuitry that is crucial for associative learning and memory. The mechanisms that underlie the development and regulation of this complex circuitry are not fully understood. Our previous study established an essential role for the zinc finger protein Zbtb20 in the specification of CA1 field identity in the developing hippocampus. Here, we show that con...

In the gerbil, brief global forebrain ischemia induces profound habituation and working memory impairments that stem from delayed hippocampal CA1 death. Short duration postischemic hypothermia has been shown to reduce CA1 loss, but such reports are controversial, as it is thought that protection may be transient. The purpose of this study was to investigate whether prolonged postischemic hypoth...

introduction: according to previous studies, colchicine causes neuronal destruction and learning depression. in this project, effects of colchicine injection into the ca1 and interaction between colchicine and nitric oxide (no) in this area on the expression of drug-seeking behavior were investigated. methods: wistar rats (250-300 g) were bilaterally cannulated at the ca1 area. colchicine (2-8 ...

background and objective: although diabetes mellitus is known to be one of the risk factors for dementia but neuropathic changes in the brain of diabetic patients have not been completely revealed. therefore, this research study was done to evaluate structural changes in pyramidal neurons of hippocampal ca1 area of male diabetic rats using golgi-impregnation method. materials and methods: male ...

ca1 region of hippocampus has an important role in learning and memory. previous reports have shown that androgens like testosterone and its metabolites are present in high concentration in ca1 region of hippocampus. androgen receptors have also high density in this region. therefore, it is suggested that neurohormones in ca1 have an important role in learning and memory. it is likely that test...

in this study the effects of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning were assessed in a t-maze, a spatial discrimination task. rats were connulated and bilateral injection of vehicle (saline) and 5-ht2a- selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) were injected through the connulae 30 miutes before training each day. results indicated that ...

The medial temporal lobe (MTL) is the first brain area to succumb to neurofibrillary tau pathology in Alzheimer's disease (AD). Postmortem human tissue evaluation suggests that this pathology propagates in an ordered manner, with the entorhinal cortex (ERC) and then CA1 stratum radiatum and stratum lacunosum-moleculare (CA1-SRLM)--two monosynaptically connected structures--exhibiting selective ...

ObjectiveThe present study validates the results of automated hippocampal subfield segmentation with histopathology in epilepsy patients undergoing surgery.MethodsWe performed an on presurgical three-dimensional, T1-weighted magnetization Prepared Rapid Acquisition Gradient Echoes Magnetic Resonance Imaging (MRI) data 25 unilateral mesial temporal lobe due to sclerosis (HS), using Freesurfer Ve...

Carbonic anhydrase I (CA1) is the cytosolic isoform of mammalian α-CA family members which are responsible for maintaining pH homeostasis in the physiology and pathology of organisms. A subset of CA isoforms are known to be expressed and function in the central nervous system (CNS). CA1 has not been extensively characterized in the CNS. In this study, we demonstrate that CA1 is expressed in the...

We have shown previously that CA1 conveys significant neural signals necessary to update value of the chosen target, namely chosen value and reward signals. To better understand hippocampal neural processes related to valuation, we compared chosen value- and reward-related neural activity between the CA3 and CA1 regions. Single units were recorded with tetrodes from the dorsal CA3 and CA1 regio...