Two metabolites have been isolated from the fermentation broth of a new species of Kitasatoa, Kitasatoa griseophaeus. These alkaloids have been identified as quinoline-2-methanol and quinoline-2-methanol acetate. The former exhibits hypoglycemic activity in the rat.

در این کار پژوهشی، نمونه‌های هیدروکسی اپتایت آلاییده با ناخالصی‌های سریم، گادولونیم و ترکیبی از دو ناخالصی به روش هیدروترمال سنتز شدند. منظور بررسی فازهای بلوری تشکیل یافته هرکدام شده، کد MAUD که یک نرم‌افزار برای تجزیه تحلیل ساختار ماده استفاده پراش بر اساس ریتولد است، شد. پاسخ دزیمتری ترمولومینسانس نمونه‌ها مورد قرار گرفت یافته‌ها نشان داد نمونه‌ ترکیبی، سطح میانی است. مشخص شد افزودن سریم می‌...

Background: The adverse effects of mefloquine and other quinoline antimalaria drugs can be severe and long-lasting. We believe that the trigger for these effects may be drug-induced hepatocellular damage that causes, firstly, a spillage of retinoids into the circulation (and hence a direct toxic effect on the brain and other target organs), and secondly, disruption of the liver-thyroid axis (an...

The title compound, C20H17F3N2O4, named tasquinimod, is a second-generation oral quinoline-3-carboxamide analogue, which is currently in phase III clinical trials for the treatment of metastatic prostate cancer. The quinoline unit is almost planar (r.m.s. deviation of fitted atoms = 0.0075 Å). The carboxamide side chain, substituted at position 3, is tilted by 88.07 (7)° to the quinoline plane....

Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of [3H]chloroquine and [3H] quinidine. These [3H]quinoline compounds became associated with hemozoin ...

Nitrogen heterocyclic compounds are used in the pharmaceutical industry, in medicine and in agriculture for their biological activity. 4-Amino-3-acetylquinoline, a new synthetically prepared quinoline derivative, was the most effective compound in our primary cytotoxic screening. In this study, we evaluated cytotoxic/antiproliferative activity of quinoline using murine leukemia cell line L1210....

Identification of the novel (E)-N'-((2-chloro-7-methoxyquinolin-3-yl)methylene)-3-(phenylthio)propanehydrazide scaffold 18 has led to the development of a new series of biologically active hydrazide compounds. The parent compound 18 and new quinoline derivatives 19-26 were prepared from the corresponding quinoline hydrazones and substituted carboxylic acids using EDC-mediated peptide coupling r...

The aim of the work is synthesis and characterization bidentate ligand
 [3-(3-acetylphenylamino)-5,5-dimethylcyclohex-3-enone][HL], from the
 reaction dimedone with 3-amino acetophenone to produce [HL], was carried out in dry benzene as a solvent under reflux.
 prepared ligand [HL] characterized by FT-IR, UV-Vis
 spectroscopy, 'H, 8C-NMR spectra, Mass (C.H.N) melting
 p...