The effects of ingestion of protein deficient or protein supplemented diets with or without sodium fluoride (NaF, 5, 10, and 20 mg/kg body wt) were studied on sperm function in mice and compared with effects on mice fed a control (standard) protein diet + NaF in the above three dose levels for 30 days. Ingestion of the protein deficient diet together with the three dose levels of NaF caused a s...

Enolase and ATPase are sensitive to fluoride. It is unclear whether this sensitivity differs for F-sensitive and F-resistant cells or for different types of fluoride. Permeabilized cells of the fluoride-sensitive strain Streptococcus mutans C180-2 and its fluoride-resistant mutant strain C180-2 FR were preincubated at pH 7 or 4 with NaF, the amine fluorides Olaflur and Dectaflur and amine chlor...

In the 1970s, 18F-labeled sodium fluoride (18F-NaF), one of the most ubiquitous positron-emitting radiopharmaceuticals, was briefly used for skeletal scintigraphy before the introduction of 99mTc-labeled diphosphonates with optimal characteristics for conventional g cameras (1,2). 18F-NaF is an analog of the hydroxyl group found in hydroxyapatite bone crystals and therefore an avid bone seeker ...

INTRODUCTION AND AIMS Adrenal insufficiency (AI) is common in patients with cirrhosis. We aimed to assess the presence of AI in stable patients with cirrhosis using the gold-standard insulin tolerance test (ITT) and to propose an algorithm for screening AI in these patients. MATERIAL AND METHODS We studied 40 stable patients with cirrhosis. We determined the basal total (BTC) and peak cortiso...

1. Adenylate cyclase activity of the washed 600g sediment of bovine corpus-luteum homogenate was solubilized by Lubrol-PX, Triton X-100 and digitonin. Digitonin was the least destructive of NaF-stimulated activity. 2. NaF, present in the solubilization medium together with MgSO4, increased the percentage yields of soluble activity from untreated 600g sediment and 600g sediment which had been pr...

Nipple aspiration fluid (NAF) can be useful for studying relevant changes in breast parenchyma and identification of potential biomarkers for detection, monitoring therapy and risk assessment of breast cancer. NAF has been investigated extensively for identification of protein biomarkers using approaches such as ELISA, immunoassay, western blot for chosen individual protein markers such as pros...

BACKGROUND The primary aim of this study was to examine if factors such as renal function, height, weight and age could affect the uptake of sodium fluoride-18 (NaF-18) by the normal bone. This is the first study to examine the possible factors that can influence NaF-18 uptake in the normal bone. METHODS A retrospective study was done on NaF-18 PET/CT bone scans from January 2010 to May 2012 ...

With the development of high-throughput metabolic technologies, a plethora of primary and secondary compounds have been detected in the plant cell. However, there are still major gaps in our understanding of the plant metabolome. This is especially true with regards to the compartmental localization of these identified metabolites. Non-aqueous fractionation (NAF) is a powerful technique for the...

Here, to understand the molecular mechanisms underlying cell death induced by sodium fluoride (NaF), we analyzed gene expression patterns in rat oral epithelial ROE2 cells exposed to NaF using global-scale microarrays and bioinformatics tools. A relatively high concentration of NaF (2 mM) induced cell death concomitant with decreases in mitochondrial membrane potential, chromatin condensation a...

Diabetes is a major frequent cause of atherosclerosis vascular disease. Arterial calcification in diabetic patients is responsible for peripheral vascular involvement. Molecular imaging using (18)F-sodium fluoride ((18)F-NaF) positron emission tomography (PET)/computed tomography (CT) has been recently proposed as a marker to study the in vivo mineralization process in the atheroma plaque. A 69...