نتایج جستجو برای: ژن atm
تعداد نتایج: 29257 فیلتر نتایج به سال:
BACKGROUND Ataxia-telangiectasia (A-T) is a neurologic disorder caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A clinical diagnosis of A-T is confirmed by radiosensitivity testing and immunoblotting for ATM protein. Because both of these tests have long turnaround times (> or =3 months), we developed a rapid immunoassay to measure ATM protein and determined its sensitivity...
ATM and ATR are two redundant checkpoint kinases essential for the stable maintenance of telomeres in eukaryotes. Previous studies have established that MRN (Mre11-Rad50-Nbs1) and ATRIP (ATR Interacting Protein) interact with ATM and ATR, respectively, and recruit their partner kinases to sites of DNA damage. Here, we investigated how Tel1(ATM) and Rad3(ATR) recruitment to telomeres is regulate...
The Single European Sky Air Traffic management (ATM) Research (SESAR) project is the technological pillar of Commission’s Initiative to modernize ATM. Here, we describe process establishing SESAR and main parts project: research development (R&D) part, which led by Joint Undertaking; deployment managed Deployment Manager; ATM Master Plan, collects lays out both R&D needs. latest Plan was adopte...
ABSTRAK. Lokasi Automatic Teller Machine Bank Syariah Indonesia Tbk (ATM BSI) dapat dianalisis dengan mengambil beberapa data sesuai faktor pendukung yang akan digunakan. Faktor salah satu metode klasifikasi mining yaitu Desicion Tree untuk menentukan lokasi strategis ATM BSI sudah didirikan. adalah pada berupa pohon keputusan menyelesaikan permasalahan diperoleh dan menghasilkan aturan-aturan ...
Double strand DNA breaks in the genome lead to the activation of the ataxia-telangiectasia mutated (ATM) kinase in a process that requires ATM autophosphorylation at serine-1981. ATM autophosphorylation only occurs if ATM is previously acetylated by Tip60. The activated ATM kinase phosphorylates proteins involved in arresting the cell cycle, including p53, and in repairing the DNA breaks. Chlor...
PURPOSE Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to ataxia-telangiectasia (A-T). The histone acetylaion/deacetylation- dependent chromatin remodeling can activate the ATM kinase-mediated DNA damage signal pathway (in an accompanying work, Lee, 2007)...
Ataxia-telangiectasia and Li-Fraumeni syndrome, pleiotropic disorders caused by mutations in the genes atm and p53, share a marked increase in cancer rates. A number of studies have argued for an interaction between these two genes (for comprehensive reviews, see M. S. Meyn, Cancer Res., 55: 5991-6001, 1995, and M. F. Lavin and Y. Shiloh, Annu. Rev., Immunol., 15: 177-202, 1996). Specifically, ...
BACKGROUND Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate-risk factor for developing breast cancer. In this study, we examined whether ATM inactivation in breast canc...
PURPOSE In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may have an increased susceptibility to radiation-induced breast cancer (BC) after treatment for Hodgkin's disease (HD). We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers. EXPERIMENTAL D...
چکیده توسعه روزافزون جوامع بشری، گسترش سریع حمل و نقل هوایی را به دنبال داشته است. امروزه مدیریت ترافیک هوایی به مسئله پیچیده ای تبدیل گردیده که دانشمندان علاقه مند به حل آن می باشند. فشار زیاد کاری مراقبین پرواز، افزایش موقعیت های اضطراری پرواز، هواپیما ربایی، محدودیت فضای آزاد و غیر قابل پیش بینی بودن آن، نیاز به استقلال عمل، خودمختاری، اجازه دادن برای مسیر یابی و پیشگیری از تصادم را در مدیر...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید