P53 is a recognized tumor suppressor gene, which mainly depends on the activity of its transfer factor to realize effect. Mouse two-minute 2 (MDM2) an important inhibitor p53. When combined with MDM2, p53 will be reduced, and anti-cancer effect weakened. According mechanism between researchers focus inhibitors inhibit their binding. Through large number drug screening methods means, this articl...

ABSTRAK
 Astrositoma merupakan salah satu tumor primer susunan saraf pusat yang paling sering ditemukan dibandingkan lainnya. Tujuan penelitian ini adalah untuk mengetahui pola ekspresi protein P53 pada astrositoma berdasarkan derajat histopatologi. Penelitian observasi analitik dengan pendekatan cross sectional dilakukan di Fakultas Kedokteran Universitas Hasanuddin Makassar mulai bulan A...

unstimulated whole salivary p53 was evaluated in non-involved subjects, in patients suffering from oral lichen planus (olp) and squamous cell carcinoma (scc). a total of 34 patients with olp, 24 patients suffering from oral scc and 41 non-involved participants were enrolled. the unstimulated whole saliva p53 level was assayed by elisa. data was analyzed by anova followed by the tukey post hoc t...

p53 plays a critical role in tumor suppression and is the most frequently mutated gene human cancers. Most mutants (mutp53) are missense mutations thus expressed In cancers that retain wtp53, wtp53 activities downregulated through multiple mechanisms. For example, overexpression of negative regulators p53, MDM2/MDMX, can also efficiently destabilize inactivate wtp53. Therefore, both mutp53 have...

Background and Objectives: RCC is one of the most common genitourinary cancers. Accurate prediction of prognosis would be valuable for adjuvant trial design, counseling and effectively scheduling follow up visits. P53 is a tumor suppressor gene that expresses a protein that involved in both cell-cycle ar...

Objective: Breast cancer comprise approximately one third of malignant cases in women and is considered as the most common invasive condition in women at an age range of 15-54 years and as the second most prevalent cause of mortality at an age range of 55-74 years. Tumor inhibiting factor p53 is a vital ...