No biological function has been identified for tiny RNA transcripts that are abortively and repetitiously released from initiation complexes of RNA polymerase in vitro and in vivo to date. In this study, we show that abortive initiation affects termination in transcription of bacteriophage T7 gene 10. Specifically, abortive transcripts produced from promoter phi 10 exert trans-acting antitermin...

Topological frustration in an energetically unfrustrated off-lattice model of the helical protein fragment B of protein A from Staphylococcus aureus was investigated. This G-type model exhibited thermodynamic and kinetic signatures of a well-designed two-state folder with concurrent collapse and folding transitions and single exponential kinetics at the transition temperature. Topological frust...

We used the absorbance spectrum of the pH-sensitive dye dimethylcarboxyfluorescein to monitor intracellular pH (pHi) in the isolated perfused S3 segment of the rabbit proximal tubule, and examined the effect on pHi of switching from a HEPES to a CO2/HCO3- buffer in the lumen and/or the bath (i.e., basolateral solution). Solutions were titrated to pH 7.40 at 37 degrees C. With 10 mM acetate pres...

In this paper we introduce the concept of entropy operator for continuous systems of finite topological entropy. It is shown that it generates the Kolmogorov entropy as a special case. If $phi$ is invertible then the entropy operator is bounded with the topological entropy of $phi$ as its norm.

In this paper, we define and study two operators $Phi^s$ and $Psi^s$ with grill. Characterization and basic properties of these operators are obtained. Also, we generalize a grill topological spaces via topology $tau^s$ induced from operators $Phi^s$ and $Psi^s$.

The object of this paper is to study $(epsilon)$-Lorentzian para-Sasakian manifolds. Some typical identities for the curvature tensor and the Ricci tensor of $(epsilon)$-Lorentzian para-Sasakian manifold are investigated. Further, we study globally $phi$-Ricci symmetric and weakly $phi$-Ricci symmetric $(epsilon)$-Lorentzian para-Sasakian manifolds and obtain interesting results.

Scrubbing identifying information from narrative clinical documents is a critical first step to preparing the data for secondary use purposes, such as translational research. Evidence suggests that the differential distribution of protected health information (PHI) in clinical documents could be used as additional features to improve the performance of automated de-identification algorithms or ...

This paper presents the Personal Health Information system (PHI), which has been designed to influence health behaviours of rural women. The objective of the PHI is to offer health information to rural women to increase their awareness about menses and maternal health. The design and development process of the PHI is based on the theory of planned behaviour and employs social cues of persuasive...

Phi values are experimental measures of how the kinetics of protein folding is changed by single-site mutations. Phi values measure energetic quantities, but they are often interpreted in terms of the structures of the transition-state ensemble. Here, we describe a simple analytical model of the folding kinetics in terms of the formation of protein substructures. The model shows that Phi values...