The butyrate derivative isobutyramide (IBT) increases fetal hemoglobin (HbF) in patients with beta-hemoglobinopathies, but little is known about its usefulness for prolonged therapeutic use. We treated 8 patients with transfusion-dependent beta-thalassemia with 350 mg/kg of body weight per day of oral IBT for 126 to 384 days. During the trial period, the hemoglobin level was maintained between ...

The monoclonal antibody LRP56 recognizes a 110-kD major vault protein (lung-resistance protein [LRP]) overexpressed in several P-glycoprotein-negative (Pgp-), multidrug resistant tumor cell lines. To determine the frequency of LRP overexpression, its prognostic significance, and its relation to Pgp, we analyzed bone marrow specimens from 87 consecutive patients with acute leukemia. Diagnoses in...

S FOR TECHNOLOGISTS' SCIENTIFIC PROGRAM 474 AUTHOR INDEX 484 CALENDAR 488 PLACEMENT LXII EDITORIAL COMMUNICATIONS. All •ditorialcorr.spond.nc should b sent to the Editor, B.lton A. Burrows, M.D., 720 Harrison Ave., Boston, Mass. 02118, Phone 617-262-4474. Books and monographs covedng the use of nuclear phenomena in the diagnosis and trotment of diseas and allied fields will be reviewed as spa...

The classic Gibbard-Satterthwaite theorem says that every strategy-proof voting rule with at least three possible candidates must be dictatorial. In [McL11], McLennan showed that a similar impossibility result holds even if we consider a weaker notion of strategy-proofness where voters believe that the other voters’ preferences are i.i.d. (independent and identically distributed): If an anonymo...

1. Resumen El proceso tradicional de búsqueda en Web se encuentra limitado por los lenguajes de consulta y por la carencia de información semántica sobre el dominio al que se refiere el usuario. Esto provoca que el sistema no recupere todos los resultados relevantes y sí obtenga, por el contrario, resultados que nada tienen que ver con la consulta original. El proyecto MESIA (CAM 07T/0017/1998)...

BACKGROUND AND PURPOSE Noninvasive radiologic evaluation of glioma can facilitate correct diagnosis and detection of malignant transformation. Although positron-emission tomography is considered valuable in the care of patients with gliomas, (18)F-fluorodeoxyglucose and (11)C-methionine have reportedly shown ambiguous results in terms of grading and prognostication. The present study compared t...

This paper presents a real-time system for pedestrian tracking in sequences of grayscale images acquired by a stationary CCD camera. The objective is to integrate this system with a traffic control application such as a pedestrian control scheme at intersections. The proposed approach can also be used to detect and track humans in front of vehicles. Furthermore, the proposed schemes can be empl...

Minimally invasive posterior spinous process-splitting laminoplasty preserving the paraspinal musculature has been introduced to treat patients with lumbar spinal stenosis. Despite its theoretical advantage of limiting muscular trauma, additional efforts are required to evaluate patients' clinical and functional results following this procedure. Between 2010 and 2012, 37 patients underwent spin...

Patients with hemophilia A without human immunodeficiency virus type 1 (HIV-1) infection have lower CD4+ counts and CD4+/CD8+ ratios than controls. This is usually interpreted as a therapy-induced immunodeficiency. Our data re-examine the effect of therapy on peripheral blood mononuclear cell immunophenotypic subpopulations in all congenital clotting disorders. Since late 1985 we have prospecti...

INTRODUCTION AND OBJECTIVES Psoriasis is a chronic inflammatory disease that has been linked to increased cardiovascular risk. The glycoprotein clusterin (apolipoprotein J) is a component of high-density lipoproteins and has a protective role in atherosclerosis. The aim of the present study was to evaluate the plasma levels of clusterin and the proinflammatory cytokine macrophage migration inhi...