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PURPOSE The PI3K/Akt/mTOR pathway is activated in most castration-resistant prostate cancers (CRPC). Transcriptionally active androgen receptor (AR) plays a role in the majority of CRPCs. Therefore, cotargeting full-length (FL) AR and PI3K/Akt/mTOR signaling has been proposed as a possible, more effective therapeutic approach for CRPC. However, truncated AR-splice variants (AR-V) that are const...
We demonstrate the deposition of fully dense, stoichiometric TiN films on amorphous SiO2 by reactive high power impulse magnetron sputtering (HiPIMS) in the absence of both substrate heating and applied bias. Contrary to the highly underdense layers obtained by reactive dc magnetron sputtering (dcMS) under similar conditions, the film nanostructure AC C EP TE D M AN U SC R IP T ACCEPTED MANUSCR...
INTRODUCTION KIR2DS5 is an activating human NK cell receptor of lineage III KIR. These include both inhibitory KIR2DL1, 2 and 3 and activating KIR2DS1 that recognize either the C1 or C2 epitope of HLA-C. In Europeans KIR2DS5 is essentially monomorphic, with KIR2DS5*002 being predominant. Pioneering investigations showed that KIR2DS5*002 has activating potential, but cannot recognize HLA-A, -B, ...
HYPOTHESIS Preoperative and intraoperative variables predict in part adverse outcome after liver transplantation. DESIGN Prospective, blinded, cohort study. SETTING Tertiary care hospital. SUBJECTS A total of 190 adult patients undergoing primary liver transplantation. MAIN OUTCOME MEASURE Adverse outcome was prospectively defined as either in-hospital death or prolonged postoperative h...
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