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An E1B 55 kDa gene-deleted adenovirus, Onyx-015, which reportedly selectively replicates in and lyses p53-deficient cells, was administered by a single intratumoral injection to a total of 22 patients with recurrent head and neck cancer. The objectives of this Phase I study were to determine the safety, feasibility, and efficacy of this therapy and determine any correlation to p53 status. Six c...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide; however, only limited therapeutic treatments are available. Hence, we investigated the role of cannabinoid receptors, CB1 and CB2, as novel therapeutic targets against NSCLC. We observed expression of CB1 (24%) and CB2 (55%) in NSCLC patients. Furthermore, we have shown that the treatment of NSCLC cell lines (A5...
1. German Society for Gynecology and Obstetrics 2. Study Group for Urogynecology and Plastic Pelvic Floor Reconstruction of the German Society for Gynecology and Obstetrics 3. Study Group for Urogynecology and Reconstructive Pelvic Floor Surgery, Austria 4. Study Group for Urogynecology and Reconstructive Pelvic Floor Surgery, Switzerland 5. Surgical Study Group for Coloproctology 6. Profession...
Normal vaginal flora of sexually mature women consists of lactobacilli, transient or commensal anaerobic and aerobic bacteria, and Candida species from skin and gut flora. The normal pH value of vaginal flora is 3.8–4.4. Lactobacilli predominate in the vaginal flora, primarily L. crispatus, L. gasseri, L. iners and L. jensenii, depending on ethnicity. Normal pH values differ significantly betwe...
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