Dupilumab, a fully human IgG4 monoclonal antibody targeting the interleukin-4 receptor alpha (IL4Rα), substantially improves disease severity in patients with atopic dermatitis (AD). While recent daily practice studies have shown that dose reduction of dupilumab is possible controlled AD, associated biological effects are currently unknown. Therefore, we studied levels serum and on IL4Rα occupa...

A synthetic feline TRIM5-cyclophilin A fusion protein (feTRIMCyp) was generated and transduced into feline cells. feTRIMCyp was highly efficient at preventing infection with human (HIV) and feline (FIV) immunodeficiency virus pseudotypes, and feTRIMCyp-expressing cells resisted productive infection with either FIV-Fca or FIV-Pco. The restriction of FIV infection by feTRIMCyp was reversed by the...

Juvenile hormone (JH) plays key roles in controlling insect growth and metamorphosis. However, relatively little is known about the JH signaling pathways. Until recent years, increasing evidence has suggested that JH modulates the action of 20-hydroxyecdysone (20E) by regulating expression of broad (br), a 20E early response gene, through Met/Gce and Kr-h1. To identify other genes involved in J...

Twenty five advanced lines among them twelve lines obtained from the cross between Edible Podded Pea and IPSA Motorsuty-1, nine obtained from the cross between Local White and IPSA Motorsuty-3 and five parental lines were included to measure genetic diversity. The field experiment was conducted at the research farm, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh....

In seeking to identify nucleating/antinucleating proteins involved in the pathogenesis of cholesterol gallstones, a major acidic protein was isolated from each of 13 samples of cholesterol gallstones. After the stones were extracted with methyl t-butyl ether to remove cholesterol, and methanol to remove bile salts and other lipids, they were demineralized with EDTA. The extracts were desalted w...

El presente trabajo presenta el Diagnóstico del consumo de energía eléctrica nivel básico, también conocido como I, en un Hotel cuatro estrellas Ciudad Valles, S.L.P. Para lo cual se revisó la facturación Comisión Federal Electricidad (CFE) 2019, revisión sistema iluminación, climatización y otros equipos consumidores eléctrica. iluminación realizaron mediciones con procedimiento NOM-025-STPS-2...