In Kenya, Leishmania major is responsible for human cutaneous leishmaniasis (CL). Natural infection with L. major of a vervet monkey and experimental susceptibility of some nonhuman primates (NHPs) from Kenya has been established. However, there has been no comprehensive study of the prevalence of zoonotic CL in Kenya. And also, no investigation has been done to assess whether NHPs could be pot...

Prolyl cis/trans isomerizations determine the rates of protein folding reactions and can serve as molecular switches and timers. In the gene-3-protein of filamentous phage, Pro-213 trans --> cis isomerization in a hinge region controls the assembly of the 2 domains N1 and N2 and, in reverse, the activation of the phage for infection. We elucidated the structural and energetic basis of this prol...

Comparison of Flow Routing Algorithms Used in Geographic Information Systems Track: Water Resources Author(s): Christine Lam, John Wilson This paper reports the results of a series of experiments to evaluate the performance of five flow routing algorithms that have been implemented inside one or more GIS. A fuzzy classification was used to delineate landscape classes (hilltops, steep slopes, fo...

The antitumor agent VP-16-213 is oxidatively O-demethylated by rat liver microsomes and purified rat liver microsomal cytochrome P-450. 3-Methylcholanthrene can quantitatively induce O-demethylation of VP-16-213. The Km and Vmax values for O-demethylation by noninduced, phenobarbital-, and 3-methylcholanthrene-induced rat liver microsomes were found to be 130, 600, and 160 microM and 8.5, 11.8,...

INTRODUCTION ........................................................... 208 ORGANELLE GENOME SIZE AND SHAPE ........................................ 208 Size and Shape of Mitochondrial Deoxyribonucleic Acids (DNAs) ...... ............... 209 Size and Shape of Chloroplast DNAs.............................................. 212 GENE ARRANGEMENT IN ORGANELLE DNAs ......... ...........................