OBJECTIVE The aim of this study was to investigate the association of plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene polymorphism and osteonecrosis of the femoral head (ONFH). METHODS The pooled relative risk ratio (RR) and 95% confidence intervals (95% CI) were calculated using the the RevMan 5.0 software. RESULTS The present study included 969 patients with ONFH and 419 healthy cont...

The polymorphism of the thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1) was analyzed and was compared with the restriction fragment length polymorphism (RFLP) of the whole genome to evaluate the relative efficiency of the TK gene as a potential probe for identification and discrimination of HSV-1. The effectiveness of using the polymorphism of the TK gene in classifying HSV-1 ...

  Abstract   Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome   position 1q42, was initially identified at the breakpoint of a balanced translocation,   t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large   Scottish family.   Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia   on the basis of DSM-IV criteria an...

Topic 1: Gene polymorphisms and the neuroendocrine immune system in rheumatic diseases Christoph Baerwald, Leipzig (D): Corticotropin-releasing hormone promoter polymorphism – what is the reality J.A. Cidlowski, Research Triangle Park, NC: Glucocorticoid receptor beta gene variant Marco Matucci-Cerinic, Florence (I): ACE polymorphism and scleroderma Lars Klareskog Stockholm (S): Polymorphism al...

BACKGROUND The ICAM-1 +469 A/G polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The present meta-analysis aimed to investigate the association between the ICAM-1 +469 A/G polymorphism and cancer risk. METHODS We searched PubMed, Embase to identify studies that evaluated the association between the ICAM-1 +469 A/G polymorphism and cancer risk. Da...

Objectives. Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity. We hypothesized that genetic variation in PECAM-1 gene could be associated with diabetic nephropathy (DN) and with the level of soluble PECAM-1 in Caucasians with type 2 diab...

Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with ATL and inflammatory diseases but remains a neglected health problem. HTLV-1 associated diseases were originally described as sporadic entities, but family aggregations have been reported. Viral, genetic, immunological and behavioral factors were used to explain family clusters, but until now a clear explanation remains un...