Twins have an increased risk of being small-for-gestational-age (SGA) at birth compared to singletons, but little is known about their growth in childhood. It’s hypothesized that the maternal-fetal unit may become less capable sustaining optimal twin fetuses starting around 32 weeks indicating some smaller size be due adaptation. Whether SGA twins show same postnatal patterns as singletons born...

BACKGROUND Increasing livestock density and animal manure spreading, along with climate factors such as heavy rainfall, may increase the risk of acute gastrointestinal illness (AGI). In this study we evaluated the association between farming activities, precipitation and AGI. METHODS A cross-sectional telephone survey of randomly selected residents (n = 7006) of 54 rural municipalities in Que...

BACKGROUND Low birth weight (LBW) is associated with adult-onset diseases, including hypertension and renal disease; altered renal development after intrauterine growth restriction (IUGR) may underlie related prenatal programming. No data are available on longitudinal renal growth in twin infants born small for gestational age (SGA). The aim of this prospective longitudinal study was to estimat...

OBJECTIVE Insulin resistance has been linked to intrauterine growth retardation (IUGR); adiponectin is a protein with insulin-sensitizing properties. This study was designed to test whether being born small for gestational age (SGA) has an effect on blood levels of adiponectin and leptin, insulin resistance parameters, and lipid profile in pre-puberty, taking into consideration the severity of ...

abstract:introduction: racial and environmental differences in communities leading cause of differences in serum lipids. it can be said this study aimed in assessing percentile curves of serum lipid profile about 6-18 years old students of birjand.method: the present cross-sectional study was done on 4168 students of birjand aged 6-18 years. they were classified into three age groups 6-10 and 1...

The individualized reference for defining small for gestational age (SGA) at birth has gained popularity in recent years. However, its utility on fetal assessment has not been evaluated. The authors compare an individualized with an ultrasound reference in predicting poor perinatal outcomes. Data from a large clinical trial in predominantly white US women (1987-1991) with singleton pregnancies ...

There is conflicting information about the influence of body mass index (BMI) on the pharmacokinetics, toxicity, and outcome of chemotherapy. We compared pharmacokinetics, outcome, and toxicity data across 4 BMI groups (underweight, BMI < 10th percentile; normal; at risk of overweight, BMI > 85th and < 95th percentile; overweight, BMI > 95th percentile) in 621 children with acute lymphoblastic ...

BACKGROUND Low birth weight (LBW) has been linked to renal disease both in animal models and human studies. However, the role of birth weight in the development of diabetic nephropathy is unclear. We, therefore, studied the impact of birth weight on the development of diabetic nephropathy and other related traits, such as diabetic retinopathy and macrovascular disease, in Caucasian type 1 diabe...

We evaluated magnetic resonance imaging (MRI) voxel heterogeneity following trastuzumab and/or cisplatin in a HER2+ esophageal xenograft (OE19) as a potential response biomarker. OE19 xenografts treated with saline (controls), monotherapy, or combined cisplatin and trastuzumab underwent 9.4-T MRI. Tumor MRI parametric maps of T1 relaxation time (pre/post contrast), T2 relaxation time, T2* relax...

CONTEXT Maternal transfer of heavy metals during fetal development or lactation possibly contributed to the clinical manifestations of Bartter syndrome and developmental delay in the offspring. CASE PRESENTATION An 11-month-old child diagnosed with Bartter syndrome and failure to thrive was treated concurrently for elevated metal burden while he was undergoing standard medical interventions. ...