In 2008, clinicians performing routine medical examinations in the United States reported high rates of hematologic and neurologic disorders caused by vitamin B12 deficiency in resettled Bhutanese refugees. To confirm this finding, CDC screened Bhutanese refugees' serum samples for vitamin B12 levels and found vitamin B12 deficiency in 64% (n = 99) of samples obtained before departure and 27% (...

Vitamin B12 deficiency is a major public health problem: however, there is no consensus on how to diagnose this deficiency. In the present review we attempt to give a balanced update. We include only issues related to diagnosing and treating vitamin B12 deficiency in the adult population and do not cover inherited diseases of vitamin B12 deficiency except for those related to classical pernicio...

The vitamin B(12) level and the capacity of serum to bind B(12) are higher in the West Indian population living in Great Britain than in Europeans. The B(12) level fell during pregnancy in both groups but remained higher in the West Indians. West Indians had higher levels of IgG.

OBJECTIVE To describe the prevalence of biochemical B(12) deficiency in adults with type 2 diabetes taking metformin compared with those not taking metformin and those without diabetes, and explore whether this relationship is modified by vitamin B(12) supplements. RESEARCH DESIGN AND METHODS Analysis of data on U.S. adults ≥50 years of age with (n = 1,621) or without type 2 diabetes (n = 6,8...

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Evidence is presented that after injection of radioactive vitamin B(12) in man, there is a close correlation between the amount of radioactivity excreted and the amount of assayable vitamin B(12) excreted, and thus that the amount of radioactivity excreted is a true measure of the vitamin B(12) excreted. The possible reasons for this occurrence are discussed and it is suggested that in the body...