UNLABELLED The replication of hepatitis C virus (HCV) is uniquely dependent on a host microRNA, miR-122. Previous studies using genotype 1a H77S.3 virus demonstrated that miR-122 acts in part by protecting the RNA genome from 5' decay mediated by the cytoplasmic 5' exoribonuclease, Xrn1. However, this finding has been challenged by a recent report suggesting that a predominantly nuclear exoribo...

In this issue of JCI, two independent groups describe the effects of germline and liver-specific deletion of Mir122a, the predominant liver miRNA. Their findings reveal a critical role for miR-122 in fat and cholesterol metabolism but suggest that other metabolic actions of the liver are independent of miR-122. Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of...

Citation Coleman, J. J., H. van der Sijs, W. E. Haefeli, S. P. Slight, S. E. McDowell, H. M. Seidling, B. Eiermann, et al. 2013. “Correction: On the alert: future priorities for alerts in clinical decision support for computerized physician order entry identified from a European workshop.” BMC Medical Informatics and Decision Making 13 (1): 122. doi:10.1186/14726947-13-122. http://dx.doi.org/10...

MicroRNA molecules have been increasingly regarded as a diagnostic and prognostic marker of certain diseases. The aim of this study was to investigate the expression and clinical significance of miR-122 and miR-29 in liver disease related to hepatitis B virus infection. The serum levels of miR-122 and miR-29 in 20 patients with hepatocellular carcinoma (HCC), 20 patients with liver cirrhosis (L...

AMA Kashuba N, Melnyk N. DETERMINATION OF THE EPIDEMIC THRESHOLD AN INFECTIOUS DISEASE. Health Problems of Civilization. 2023;17(2):122-129. doi:10.5114/hpc.2023.126726. APA Kashuba, N., & Melnyk, (2023). Civilization, 17(2), 122-129. https://doi.org/10.5114/hpc.2023.126726 Chicago Nikolay, and Nataliia Melnyk. 2023. "DETERMINATION DISEASE". Civilization 17 (2): Harvard pp.122-129. MLA Nikolay ...

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels. Efficient and specific depletion of miR-122 by injection of a lock...

MicroRNA-122 (miRNA-122), also known as liver-specific miRNA, has recently been shown to be a potent biomarker in response to liver injury in mammals. The objective of this study was to examine its expression in response to toxicant treatment and acute liver damage, using the zebrafish system as an alternative model organism. For the hepatotoxicity assay, larval zebrafish were arrayed in 24-wel...

OBJECTIVE Our previous study has found that circulating microRNA (miRNA, or miR) -122, -140-3p, -720, -2861, and -3149 are significantly elevated during early stage of acute coronary syndrome (ACS). This study was conducted to determine the origin of these elevated plasma miRNAs in ACS. METHODS qRT-PCR was performed to detect the expression profiles of these 5 miRNAs in liver, spleen, lung, k...

Liver injury is a major hindrance to the treatment of tuberculosis (TB) patients due to the primary side effects associated with anti-TB drugs. Several investigations have identified sensitive biomarkers for the early diagnosis of anti-TB drug-induced liver injury (ADLI), including the use of microRNAs (miRNAs/miRs). However, the association between miR-122/155 and ADLI remains unknown. Thus, t...

BACKGROUND Hepatitis C virus genotype 4 (HCV-4) infection is common in the Middle East and Africa, with an extraordinarily high prevalence in Egypt. MicroRNAs (miRNAs) play an important role in various diseases, including HCV infection. The aim of the present study was to assess serum miR-122, miR-221 and miR-21 expression profiles in HCV-4 patients prior to treatment with HCV-4 combination the...