BACKGROUND Pan-resistant Acinetobacter infection has emerged as an important nosocomial pathogen in our inpatient neonates over the past few years. METHODOLOGY We performed a retrospective chart review during a five-year period (July 2003 - June 2008) of all neonates hospitalized in our neonatal intensive care unit (NICU) who developed Acinetobacter infection to identify mortality-associated ...

Fungal contamination and the presence of related toxins is a widespread problem. Mycotoxin contamination has prompted many countries to establish appropriate tolerance levels. For instance, with the Commission Regulation (EC) N. 1881/2006, the European Commission fixed the limits for the main mycotoxins (and other contaminants) in food. Although valid analytical methods are being developed for ...

miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells. miR-122 attenuates the epithelial-mesenchymal transition process, which mediates cancer cells m...

The locus of enterocyte effacement (LEE) and genomic O island 122 (OI-122) are pathogenicity islands in verocytotoxin-producing Escherichia coli (VTEC) serotypes that are associated with outbreaks and serious disease. Composed of three modules, OI-122 may occur as "complete" (with all three modules) or "incomplete" (with one or two modules) in different strains. OI-122 encodes two non-LEE effec...

BACKGROUND Circulating microRNA-122 (miR-122) has been increasingly reported to be a potential biomarker for drug-, viral-, alcohol- and chemical-induced liver injury. The present study was initiated to determine the potential of circulating miR-122 as a biomarker for cholestatic liver injury. METHODS Both bile-duct ligation (BDL) mice and patients with biliary calculi were employed as choles...

Genom tarafından kodlanan tek iplikli RNA molekülü olan ve biyolojik süreçlerde rol oynayan mikroRNA'lar, pek çok dokuda ifade edilmekte serum düzeyleri doku hasarı hakkında bilgi sağlamaktadır. Bunlardan biri miR-122, insanlarda karaciğer hasarından sonra kanda belirlenebilen doğrulanmış bir biyobelirteçtir. İnsanlarda olduğu gibi köpeklerde de klasik fonksiyon testleri (aminotransferazlar) öz...