نتایج جستجو برای: 1343
تعداد نتایج: 543 فیلتر نتایج به سال:
OBJECTIVES The aim of this study was to evaluate the influence of total drainage time on the risk of catheter infection, and the predictive value of standard laboratory examinations for the diagnosis of bacteriologically recorded cerebrospinal fluid (CSF) infection during external ventricular drainage. METHODS During a three year period, all patients of the neurosurgical intensive care unit (...
Numerous epidemiologic studies report an inverse association between increasing levels of regular physical activity and reductions in major morbidity and mortality. Clinical guidelines emphasize the importance of specific amounts of regular physical activity, yet the majority of US adults do not meet these recommended levels. There are comparatively less data on nonexercise, or lifestyle, physi...
The healthy heartbeat is traditionally thought to be regulated according to the classical principle of homeostasis whereby physiologic systems operate to reduce variability and achieve an equilibrium-like state [Physiol. Rev. 9, 399-431 (1929)]. However, recent studies [Phys. Rev. Lett. 70, 1343-1346 (1993); Fractals in Biology and Medicine (Birkhauser-Verlag, Basel, 1994), pp. 55-65] reveal t...
Genome-wide association studies (GWASs) have proven highly effective, identifying hundreds of associations across numerous complex diseases. These studies typically test hundreds of thousands of variations and identify hundreds of potential associations. However, to date, follow-up attempts have generally only concentrated on just the few most significant initial associations, leaving the major...
A new approach is presented for the development of quantitative structure–property relations (QSPR) based on the extraction of relevant molecular features with self-organizing maps and the use of a modified fuzzy-ARTMAP classifier for variable prediction. The present methodology is demonstrated for the development of a QSPR for the aqueous-phase infinite dilution activity coefficient , based on...
Usher syndrome (USH) is a group of disorders manifested as retinitis pigmentosa and bilateral sensorineural hearing loss, with or without vestibular dysfunction. Here, we recruited three Chinese families affected with autosomal recessive USH for detailed clinical evaluations and for mutation screening in the genes associated with inherited retinal diseases. Using targeted next-generation sequen...
The syntheses of the perfluorinated alcohols (F(5)C(6))(F(3)C)(2)COH (1) and (F(5)C(6))(C(5)F(10))COH (2) are described. Both compounds were prepared in reasonable yields (1: 65%, 2: 85%) by reacting the corresponding ketone with C(6)F(5)MgBr, followed by acidic work-up. The alcohols were characterized by NMR, vibrational spectroscopy, single-crystal X-ray diffraction, acidity measurements and ...
BACKGROUND Childhood overweight/obesity is increasing rapidly in developing countries. There is a need to provide more evidence on its burden in sub-Saharan Africa, and to identify associated factors in order to set preventive measures. We aimed to determine the prevalence of overweight/obesity and assess its association with the socioeconomic status in nursery and primary school children in ur...
BACKGROUND Improving the cost-effectiveness of health care requires an understanding of the genesis of health care costs and in particular the sources of cost variation. Little is known about how multiple physicians, caring collaboratively for patients, contribute to costs. OBJECTIVE To explore the effect of collaborative care by physicians on variation in discretionary costs in an intensive ...
BACKGROUND AND PURPOSE Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake with mortality from cardiovascular disease for Japanese men and women. METHODS The subjects were 23,119 men and 35 611 women aged 40 to 79 years without a hi...
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